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　　2001年畢業于山東大學，獲學士學位;2006年畢業于中科院生化與細胞所，獲博士學位。2006年12月至2012年7月于美國哈佛醫學院/以色列女執事醫學中心(Harvard Medical School/Beth Israel Deaconess Medical Center)從事博士后研究。2012年7月底回國就任中國科學院生物化學與細胞生物學研究所研究員，研究組長。

腫瘤細胞的一個重要特征是近乎無限的分裂增殖。這種表型可能由多種生理過程的異常所引起，包括細胞周期負調因子的缺失突變、細胞代謝途徑的超常活躍、關鍵信號通路的活化及細胞凋亡通路的異常等。本實驗室的研究興趣主要集中于調控腫瘤細胞生長增殖的核心信號轉導與細胞代謝調節機制方面，特別是發現關鍵信號蛋白的重要翻譯后修飾，從而詮釋腫瘤細胞生長增殖/癌癥發生發展的分子機制，并為癌癥的臨床治療提供新的思路與治療靶點。

1. Gao, D., H. Inuzuka, A. Tseng, R. Y. Chin, A. Toker, and W. Wei*. "Phosphorylation by Akt1 Promotes Cytoplasmic Localization of Skp2 and Impairs Apccdh1-Mediated Skp2 Destruction." Nature Cell Biology , no. 4 (2009): 397-408.
2. Gao, D., H. Inuzuka, M. Korenjak, A. Tseng, T. Wu, L. Wan, M. Kirschner, N. Dyson, and W. Wei*. "Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2f1 Pathways." Molecular Biology of the Cell , no. 14 (2009): 3305-16.
3. Gao, D., L. Wan, H. Inuzuka, A. H. Berg, A. Tseng, B. Zhai, S. Shaik, E. Bennett, A. E. Tron, J. A. Gasser, A. Lau, S. P. Gygi, J. W. Harper, J. A. DeCaprio, A. Toker, and W. Wei*. "Rictor Forms a Complex with Cullin-1 to Promote Sgk1 Ubiquitination and Destruction." Molecular Cell , no. 5 (2010): 797-808.
4. Gao, D., H. Inuzuka, M. K. Tan, H. Fukushima, J. Locasale, P. Liu, L. Wan, B. Zhai, Y. R. Chin, S. Shaik, C. Lyssiotis, S. Gygi, A. Toker, L. Cantley, J. Asara, J. W. Harper, and W. Wei*. "Mtor Drives Its Own Activation Via Scf Βtrcp-Dependent Degradation of the Mtor Inhibitor Deptor." Molecular Cell, no. 2 (2011): 290-303.
5. Inuzuka, H., D. Gao, L. W. S. Finley, W. Yang, L. Wan, H. Fukushima, Y. R. Chin, B. Zhai, S. Shaik, A. W. Lau, Z. Wang, S. P. Gygi, K. Nakayama, J. Teruya-Feldstein, A. Toker, M. C. Haigis, P. P. Pandolfi, and W. Wei*. "Acetylation-Dependent Regulation of Skp2 Function." Cell, no. 1 (2012): 179-93.
6. Hu, H., W. Zhu, J. Qin, M. Chen, L. Gong, L. Li, X. Liu, Y. Tao, H. Yin, H. Zhou, L. Zhou, D. Ye, Q. Ye, and D. Gao.* "Acetylation of Pgk1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis." Hepatology , no. 2 (2017): 515-28.
7. Liu, X., M. Chen, L. Li, L. Gong, H. Zhou, and D. Gao.* "Extracellular Signal-Regulated Kinases (Erks) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation." Journal of Biological Chemistry , no. 10 (2017): 3970-76.
8. Xie, X., H. Hu, X. Tong, L. Li, X. Liu, M. Chen, H. Yuan, X. Xie, Q. Li, Y. Zhang, H. Ouyang, M. Wei, J. Huang, P. Liu, W. Gan, Y. Liu, A. Xie, X. Kuai, G. W. Chirn, H. Zhou, R. Zeng, R. Hu, J. Qin, F. L. Meng, W. Wei, H. Ji, and D. Gao.* "The Mtor-S6k Pathway Links Growth Signalling to DNA Damage Response by Targeting Rnf168." Nature Cell Biology , no. 3 (2018): 320-31.
9. Cui, B., L. Gong, M. Chen, Y. Zhang, H. Yuan, J. Qin, and D. Gao.* "Cul5-Socs6 Complex Regulates Mtorc2 Function by Targeting Sin1 for Degradation." Cell Discovery , no. 1 (2019).
10. Zhao, G., L. Gong, D. Su, Y. Jin, C. Guo, M. Yue, S. Yao, Z. Qin, Y. Ye, Y. Tang, Q. Wu, J. Zhang, B. Cui, Q. Ding, H. Huang, L. Hu, Y. Chen, P. Zhang, G. Hu, L. Chen, K. K. Wong, D. Gao*, and H. Ji*."Cullin5 Deficiency Promotes Small-Cell Lung Cancer Metastasis by Stabilizing Integrin Β1." Journal of Clinical Investigation , no. 3 (2019): 972-87.
11. Kuai, X., L. Li, R. Chen, K. Wang, M. Chen, B. Cui, Y. Zhang, J. Li, H. Zhu, H. Zhou, J. Huang, J. Qin, Z. Wang, W. Wei, and D. Gao.* "Scffbxw7/Gsk3β-Mediated Gfi1 Degradation Suppresses Proliferation of Gastric Cancer Cells." Cancer Research , no. 17 (2019): 4387-98.
12. Gao, Q., H. Zhu, L. Dong, W. Shi, R. Chen, Z. Song, C. Huang, J. Li, X. Dong, Y. Zhou, Q. Liu, L. Ma, X. Wang, J. Zhou, Y. Liu, E. Boja, A. I. Robles, W. Ma, P. Wang, Y. Li, L. Ding, B. Wen, B. Zhang, H. Rodriguez, D. Gao,* H. Zhou,* and J. Fan*. "Integrated Proteogenomic Characterization of Hbv-Related Hepatocellular Carcinoma." Cell , no. 2 (2019): 561-77.e22.
13. Dong, L., D. Lu, R. Chen, Y. Lin, H. Zhu, Z. Zhang, S. Cai, P. Cui, G. Song, D. Rao, X. Yi, Y. Wu, N. Song, F. Liu, Y. Zou, S. Zhang, X. Zhang, X. Wang, S. Qiu, J. Zhou, S. Wang, X. Zhang, Y. Shi, D. Figeys, L. Ding, P. Wang, B. Zhang, H. Rodriguez, Q. Gao,* D. Gao,* H. Zhou,* and J. Fan.* "Proteogenomic Characterization Identifies Clinically Relevant Subgroups of Intrahepatic Cholangiocarcinoma." Cancer Cell, no. 1 (2022): 70-87.e15.
14. Luo, D., M. Chen, Q. Li, K. Wang, K. Wang, J. Li, G. Fu, Z. Shan, Q. Liu, Y. Yang, L. Liang, Y. Ma, Y. Qin, J. Qin, D. Gao, *and X. Li.* "Cul4b-Ddb1-Cop1-Mediated Utx Downregulation Promotes Colorectal Cancer Progression." Experimental Hematology and Oncology , no. 1 (2023).
15. Chen, M., K. Wang, Y. Han, S. Yan, H. Yuan, Q. Liu, L. Li, N. Li, H. Zhu, D. Lu, K. Wang, F. Liu, D. Luo, Y. Zhang, J. Jiang, D. Li, L. Zhang, H. Ji, H. Zhou, *Y. Chen, *J. Qin,* and D. Gao.* "Identification of Xaf1 as an Endogenous Akt Inhibitor." Cell Reports , no. 7 (2023).
16. Duan, J., Y. Zhang, R. Chen, L. Liang, Y. Huo, S. Lu, J. Zhao, C. Hu, Y. Sun, K. Yang, M. Chen, Y. Yu, J. Ying, R. Huang, X. Ma, S. Leaw, F. Bai, Z. Shen, S. Cai, D. Gao, J. Wang, *and Z. Wang.* "Tumor-Immune Microenvironment and Nrf2 Associate with Clinical Efficacy of Pd-1 Blockade Combined with Chemotherapy in Lung Squamous Cell Carcinoma." Cell Reports Medicine , no. 12 (2023).
17. Gao, D., and G. Ge. "Exploring the Underlying Biology of Cancer and Potential Therapeutic Strategies: A Special Issue Focused on Mechanism-Based Studies." Acta Biochimica et Biophysica Sinica , no. 6 (2023): 891-92.
18. Liu, Q., J. Zhang, C. Guo, M. Wang, C. Wang, Y. Yan, L. Sun, D. Wang, L. Zhang, H. Yu, L. Hou, C. Wu, Y. Zhu, G. Jiang, H. Zhu, Y. Zhou, S. Fang, T. Zhang, L. Hu, J. Li, Y. Liu, H. Zhang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. Gao,* H. Ji,* H. Zhou,* and P. Zhang.* "Proteogenomic Characterization of Small Cell Lung Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies." Cell , no. 1 (2024): 184-203.e28.
19. Yu, J., X. Gui, Y. Zou, Q. Liu, Z. Yang, J. An, X. Guo, K. Wang, J. Guo, M. Huang, S. Zhou, J. Zuo, Y. Chen, L. Deng, G. Yuan, N. Li, Y. Song, J. Jia, J. Zeng, Y. Zhao, X. Liu, X. Du, Y. Liu, P. Wang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, H. Zhou,* Z. Shao,* L. Wu,* and D. Gao.* "A Proteogenomic Analysis of Cervical Cancer Reveals Therapeutic and Biological Insights." Nature Communications , no. 1 (2024).
20. Wang, K., M. Chen, S. Yan, Y. Han, H. Yuan, Q. Liu, D. Lu, L. Li, K. Wang, F. Liu, Q. Li, D. Luo, J. Jiang, H. Zhou,* Y. Chen,* J. Qin,* and D. Gao.* "Zinc Ions Activate Akt and Promote Prostate Cancer Cell Proliferation Via Disrupting Akt Intramolecular Interaction." Oncogene , no. 1 (2025): 8-18.
21. Gao, D., and J. W. P. Yam. "Reversal of Lipid Metabolism as a Therapeutic Approach for Hcc." Hepatology , no. 4 (2025): 1113-15.
22. Chen, R., C. Ma, H. Qian, X. Xie, Y. Zhang, D. Lu, S. Hu, M. Zhang, F. Liu, Y. Zou, Q. Gao, H. Zhou, H. Liu, M. Lin,* G. Ge,* and D. Gao.* "Mutant Kras and Ck2 Cooperatively Stimulate Slc16a3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression." Cancer Research , no. 7 (2025): 1253-69.
23. Ji, S., L. Cao, J. Gao, Y. Du, Z. Ye, X. Lou, F. Liu, Y. Zhang, J. Xu, X. Shi, H. Wang, P. Li, Y. Li, H. Chen, Z. Yang, S. Gao, W. Zhang, D. Huang, S. Ni, M. Wei, F. Wang, Y. Wang, T. Ding, D. Jing, G. Fan, Z. Gong, R. Lu, Y. Qin, J. Chen, X. Xu, P. Wang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. K. Chang, R. H. Hruban, D. Gao, D.* Gao, G.* Jin, H.* Zhou,* J. Wu,* and X. Yu.* "Proteogenomic Characterization of Non-Functional Pancreatic Neuroendocrine Tumors Unravels Clinically Relevant Subgroups." Cancer Cell , no. 4 (2025): 776-96.e14.