天天色天天干天天日,99re国产精品,日韩一区无码

首頁全所PI名錄

人才隊伍

鄒衛國
研究員，研究組長，博士生導師
E-mail: zouwg94@@sibcb.ac.cn
實驗室主頁:

個人簡介：

1998年本科畢業于南開大學生物化學系，2003年中科院生物化學與細胞生物學研究所獲得理學博士學位。隨后在美國Scripps研究所和美國哈佛大學公共衛生學院進行博士后研究(受美國白血病淋巴瘤協會資助)。2009年獲選哈佛大學公共衛生學院Yerby Fellow。2012年獲聘美國康納爾大學和紐約州立大學布法羅分校Tenure Track助理教授職位。2012年8月回中科院生物化學與細胞生物學研究所工作，任研究員，研究組長，博士生導師。獲得國家自然科學基金委杰出青年科學基金資助，國家科技部基礎科學重大研究計劃子課題負責人，中國科學院戰略性先導科技專項（B類）子課題負責人，中華醫學會骨科分會再生醫學青年委員會組長，中華醫學會骨礦鹽與骨質疏松分會基礎組常委，中國生物工程學會轉化醫學分會常委等。

社會任職：

研究方向：

間充質干細胞與疾病

研究工作：

間充質干細胞（mesenchymal stem cells,MSC）是一種多能干細胞，可以分化成成骨細胞、軟骨細胞、脂肪細胞、肌肉細胞等。同時，間充質干細胞來源方便，易于分離、培養、擴增和純化，可以作為組織器官損傷修復的種子細胞。間充質干細胞是國內外用于干細胞臨床試驗使用最多的細胞。間充質干細胞向不同組織細胞的分化受到多種遺傳因素和表觀遺傳因素的影響，受到包括BMP、Wnt、Hedgehog等多種信號途徑的調控。調控因素的異常，導致多種疾病，包括多種先天性發育畸形、骨質疏松癥、骨性關節炎等骨科相關疾病。
?
本研究組綜合運用生物化學、分子生物學和動物模型等多種研究手段，通過建立間充質干細胞向多種細胞分化的體外高通量篩選系統，研究間充質干細胞增殖與分化的分子機理，以及構建轉基因與基因敲除小鼠研究與間充質干細胞相關的多種疾病的致病機理。實驗室近期研究方向包括：
1）研究間充質干細胞所受到的表觀調控在骨關節炎、骨質疏松及骨損傷修復過程中的作用。
2）研究間充質干細胞的衰老與骨疾病的關聯及分子基礎。
3）研究機械力對于間充質干細胞功能及骨結構的調控機制。
4）研究骨損傷修復中間充質干細胞的起源、增殖及命運決定的機制。

承擔科研項目情況：

代表論著：

1. Wang L#, You X#, Ruan D#, Shao R, Dai H, Shen W, Xu G, Liu W, Zou W*. (2022) TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 13(1):4709.
2. Gao B#, Jiang B#, Xing W, Xie Z, Luo Z*, Zou W*. (2022) Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Advanced Science. 9(13): e2104888.
3. Suo J #, Zou S#, Wang J#, Han Y, Zhang L, Lv C, Jiang B, Ren Q, Chen L, Yang L, Ji P, Zheng X*, Hu P*, Zou W*. (2022) The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research. 10(1): 31.
4. Wang L, You X, Zhang L, Zhang C, Zou W*. (2022) Mechanical regulation of bone remodeling. Bone Research. 10(1): 16.
5. Shao R#, Zhang Z#, Xu Z, Ouyang H, Wang L, Ouyang H, Greenblatt M, Chen X, Zou W*. (2021) H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Research. 9(1): 30.
6. Feng H#, Xing W#, Han W#, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W*. (2020) Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 130(12): 6354-6365.
7. Sun J#, Feng H#, Xing W, Han Y, Suo J, Yallowitz A, Qian N, Shi Y, Greenblatt M, Zou W*. (2020) Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science Advances. 6(45): eaaz1410.
8. Suo J#, Feng X#, Li J, Wang J, Wang Z*, Zhang L*, Zou W*. (2020) VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 6(43): eaba4147.
9. Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W*. (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 11: 282.
10. Han Y, Feng H, Sun J, Liang X, Wang Z, Xing W, Dai Q, Yang Y, Han A, Wei Z, Bi Q, Ji H, Kang T *, Zou W*. (2019) Lkb1 deletion in periosteal mesenchymal progenitors induces osteogenic tumors through mTORC1 activation. Journal of Clinical Investigation. 129: 1895-1909.
11. Bai M, Han Y, Wu Yu, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W*, Li J*. (2019) Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 17: e3000350.
12. Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W*. (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 16: e2006522.
13. Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
14. Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
15. Dai Q, Xu Z, Ma X, Niu N, Zhou S, Xie F, Jiang L, Wang J*, Zou W*. (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death and Differentiation. 24: 1886–1899.
16. Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher L, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
17. Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. (2016) Cdh1 regulates Craniofacial Development via APC-dependent Activation of Goosecoid. Cell Research. 26: 699-712.
18. Liu Z, Yao X, Yan G, Xu Y, Yan J, Zou W*, Wang G*. (2016) Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nature Communications. 7: 11149.
19. Zou W*, Greenblatt M, Brady N, Lotinun S, Zhai B, de Rivera H, Singh A, Sun J, Gygi S, Baron R, Glimcher L, Jones D. (2013) The microtubule-associated protein DCAMKL1 regulates osteoblast function via repression of Runx2. Journal of Experimental Medicine. 210: 1793-806.
20. Zou W, Chen X., Shim J, Huang Z, Brady N, Hu D, Drapp R, Sigrist K, Glimcher L, Jones D*. (2011) The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13: 59–65.
21. Zou W#, Greenblatt M#, Shim J, Kant S, Zhai B, Brady B, Hu D, Gygi S, Davis R, Jones D, Glimcher L*. (2011) MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. Journal of Clinical Investigation. 121: 4383-92.
22. Wan L#, Zou W#, Gao D, Inuzuka H, Drapp R, Shaik S, Eguren M, Hu D, Malumbres M, Glimcher L, Wei W*. (2011) Cdh1 Regulates Osteoblast functions through an APC/C-independent modulation of Smurf1. Molecular Cell. 44: 721-33.

個人簡介：

社會任職：

研究方向：

研究工作：

承擔科研項目情況：

代表論著：

獲獎及榮譽：

研究組成員：