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　　1984年至1988就讀于南京大學生物系，獲學士學位。1992至1997年就讀于美國邁阿密大學醫學院生物化學與分子生物學系，獲博士學位。1998年至2001年在美國普林斯頓大學分子生物學系接受博士后訓練。2001年9月受聘于生物化學與細胞生物學研究所，任研究員，博士生導師，2002年2月至2007年1月，任中國科學院與德國馬普學會合作的青年科學家小組組長。

實驗室的長遠目標是探索真核細胞維持染色體穩定性的機制和細胞衰老的機理。真核細胞中的染色質分為常染色質和異染色質，處于常染色質區的基因表達活躍，而處于異染色質區的基因保持沉默。由于異染色質會擴展，常、異染色質之間會形成特異的“邊界”。該邊界的形成既有特異的DNA元件，也有染色質的修飾因子參與。在釀酒酵母中，位于染色體末端的端粒是研究染色質結構/功能、沉默、染色質邊界形成/調節、以及DNA復制/重組等表觀遺傳調控的很好的模型。端粒是由簡單的DNA重復序列及其結合蛋白組成。端粒對于維持染色體的穩定性，維持細胞連續分裂和防止細胞衰老具有非常重要的作用。在大多數真核生物中，端粒DNA是由特異性的反轉錄酶、即端粒酶合成的，在端粒酶缺失的情況下也可以由同源的重組途徑合成。另外，端粒也是一種典型的異染色質結構，能抑制相鄰的基因表達。
??????? 鑒于端粒的異染色質的特性，以及酵母基因組具有靈活的遺傳操作性，我們用酵母端粒作為特別的切入點來研究一些基礎問題，比如端粒是如何保持染色體穩定性的；在常染色質和異染色質之間的邊界是如何建立的；DNA雙鏈損傷或端粒復制發生時所產生的表觀遺傳信息是什么；細胞衰老的分子基礎又是什么。
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1. Yang-Yang Shao, Ning Lu, Zhen-Fang Wu, Chen Cai, Shan-Shan Wang, Ling-Li Zhang, Fan Zhou, Shi-Jun Xiao, Lin Liu, Xiao-Fei Zeng, Hua-Jun Zheng, Chen Yang, Zhi-Hu Zhao, Guo-Ping Zhao*, Jin-Qiu Zhou*, Xiao-Li Xue* & Zhong-Jun Qin*. (2018) Creating a functional single-chromosome yeast. Nature doi.org/10.1038/s41586-018-0382-x
2. Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou*. (2018) Yeast KEOPS complex regulates telomere length independently of its t6A modification function. Journal of Genetics and Genomics 45(5): 247-257
3. Zhen Zhou, Yu-Ting Liu, Li Ma, Ting Gong, Ya-nan Hu, Hong-Tao Li, Chen Cai Ling-Li Zhang, Gang Wei and Jin-Qiu Zhou*. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife 6:e30178 DOI: 10.7554/eLife.30178
4. Xiaoguang Liu, Wei Wei1, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li* and Jiemin Wong* (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 3, 17016
5. 翻譯著作:《抗衰老革命》,周金秋等譯,“上海科學技術出版社”發行(ISBN 978-7-5478-3588-3),原著《The Telomerase Revolution》(原著作者:Michael Fossel,出版商:BenBella Books Inc.)
6. Zhenfang Wu, Jun Liu, Qiong-Di Zhang, De-Kang Lv, Nian-Feng Wu and Jin-Qiu Zhou*. (2017) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Research 45(6):3308-3322
7. Jun Liu, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu , Ting Gong, Hong-Tao Li, Jin-Qiu Zhou*. (2016) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast. Aging 8(11): 2827-2847
8. Yi-Min Duan, Bo-O Zhou, Jing Peng, Xia-Jing Tong, Qiong-Di Zhang and Jin-Qiu Zhou*. (2016) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast. Journal of Genetics and Genomics 43(7): 451-465
9. 細胞端粒藏著長壽的秘密（《人民日報》“科技大觀”版）（科普文章），劉軍，周金秋，《人民日報》， 2015年5月4日，22 版
10. Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen*, Jin-Qiu Zhou*. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochemical Journal 467(3):507-515
11. Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou*. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PloS Genetics 11(3):e1005071
12. Fu XH, Duan YM, Liu YT, Cai C, Meng FL, Zhou JQ. (2014) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors, PloS One, 2014, 9(3):e90644.
13. Hu Y, Tang HB, Liu NN, Tong XJ, Dang W, Duan YM, Fu XH, Zhang Y, Peng J, Meng FL, Zhou JQ. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators, PloS Genet., 9(1):e1003208.
14. Li QJ, Tong XJ, Duan YM, Zhou JQ. (2013) Characterization of the intramolecular G-quadruplex promoting activity of Est1, FEBS Lett, 587(6):659-65.
15. Peng J and Zhou JQ (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Res. 40: 581-593
16. Zhou BO and Zhou JQ (2011) Recent transcription-induced histone H3K4 methylation inhibits gene reactivation. J. Biol. Chem. 286: 34770-776
17. Wang SS, Zhou BO and Zhou JQ (2011) Histone H3 Lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter. Mol. Cell. Biol. 31: 3171-81
18. Tong XJ, Li QJ, Duan YM, Liu NN, Zhang ML and Zhou JQ (2011) Est1 protects telomeres and inhibits subtelomeric Y’-element recombination. Mol. Cell. Biol. 31(6): 1263-1274
19. Zhou BO, Wang SS, Zhang Y, Fu XH, Dang W, Lenzmeier BA and Zhou JQ (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLoS Genet. 7: e1001272
20. Zhou BO, Wang SS, Xu LX, Meng FL, Xuan YJ, Duan YM, Wang JY, Hu H, Dong XC, Ding JP and Zhou JQ (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol. 30: 2391-2400
21. Liu NN, Han TX, Du LL and Zhou JQ (2010) A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. Cell Res. 20:963-965
22. Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Res. 20:495-498
23. Zhang ML*, Tong XJ*, Fu XH, Zhou B, Wang JY, Liao XH, Li QJ, Shen N, Ding JP and Zhou JQ (2010) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nat. Struct. Mol. Biol. 17: 202-209
24. Hu JL, Zhou BO, Zhang RR, Zhang KL, Zhou JQ and Xu GL (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc. Natl. Acad. Sci. 106: 187-192
25. Meng FL, Hu Y, Shen N, Tong XJ, Wang JY, Ding JP and Zhou JQ (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. EMBO J. 28: 1466-1478
26. Qian W, Wang JY, Jin NN, Fu XH, Lin YC, Lin JJ and Zhou JQ (2009) Ten1p promotes the telomeric DNA binding acivity of Cdc13p: an implication for its function in telomere length regulation. Cell Res. 19: 850-863
27. Zhou J, Zhou BO, Lenzmeier BA and Zhou JQ (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 37: 3699-3713
28. Chen XF, Meng FL and Zhou JQ (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genet. 5: e1000535
29. Fu XH, Meng FL, Hu Y and?Zhou JQ (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7:746-757
30. Yang CP, Chen YB, Meng FL and?Zhou JQ (2006) Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Res. 34:407-416
31. Zhang DH, Zhou B, Huang Y, Xu LX and?Zhou JQ (2006) The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Res. 34:1393-1404
32. Chen YB, Yang CP, Li RX, Zeng R and?Zhou JQ (2005) Def1p is involved in telomere maintenance in budding yeast. J. Biol. Chem. 280:24784-24791
33. Liao XH, Zhang ML, Yang CP, Xu LX and Zhou JQ (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem. J. 390:169-176
34. Zhou JQ*, Qi H*, Schulz VP, Mateyak MK, Monson EK and Zakian VA (2002) Schizosaccharomyces pombe pfh1(+) Encodes an Essential 5’ to 3’ DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases. Mol. Biol. Cell. 13:2180-2191 (*Co-first author)
35. Ivessa AS*, Zhou JQ*, Schulz VP, Monson EK and Zakian VA (2002) Saccharomyces Rrm3p, a 5’ to 3’ DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes & Dev. 16:1383-1396 (*Co-first author)
36. Zhou JQ, Monson EK, Teng SC, Schulz VP and Zakian VA (2000) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 289: 771-774
37. Ivessa AS*, Zhou JQ* and Zakian VA (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100: 479-489 (*Co-first author)
38. Zhou JQ, He H, Tan CK, Downey KM and So AG (1997) The small subunit is required for functional interaction of DNA polymerase delta with the proliferating cell nuclear antigen. Nucleic Acids Res. 27:1094-1099
39. Zhou JQ, Tan CK, So AG and Downey KM (1996) Purification and characterization of the human catalytic subunit of human DNA polymerase delta expressed in baculovirus-infected insect cells. J. Biol. Chem. 271:29740-29745