亚洲视频一区二区_AV电影在线免费观看_国模精品视频一区二区_91免费福利视频一区二区_亚洲AV成人精品一区青青草原_国产免费无码视频_亚洲无码在线不卡_亚洲精品永久久久久久_久久超碰精品国产_国产特一级一级一级黄色视频免费的_波多野结衣网址_五月天丁香婷婷蜜桃色_国产精品亚洲一区二区在线观看_免费观看黃色A一级在线视频_国产精品亚洲午夜福利AV

首頁 全所PI名錄
  • 周斌
  • 研究員，研究組長，博士生導師
  • E-mail: zhoubin@@sibcb.ac.cn
  • 實驗室主頁: https://zhoulab-tracing.sibcb.ac.cn
    個人簡介：

  • 2002年畢業于浙江大學醫學院臨床醫學系獲得MD。2006年畢業于中國醫學科學院中國協和醫科大學獲得PhD。2006年至2010年在美國哈佛大學醫學院波士頓兒童醫院從事博士后研究，并于2009年任哈佛大學醫學院講師和Research Associate。2010年9月起至2016年8月任中國科學院上海生命科學研究院營養科學研究所研究員，研究組長。2016年9月起任職于中國科學院上海生命科學研究院生物化學與細胞生物學研究所研究員，研究組長。曾獲得國際心臟研究會ISHR—“杰出研究員獎”、國家杰出青年科學基金、 “英國皇家學會-牛頓高級學者基金”、中國青年科技獎、中國科學院青年科學家獎、談家楨生命科學創新獎、科學探索獎、上海市自然科學獎一等獎、上海市青年科技杰出貢獻獎、新基石研究員、中科院青年科學家國際合作伙伴獎等。多次獲得中國科學院“優秀研究生指導教師”稱號、“中國科學院大學領雁獎”、“中科院優秀導師獎”、“朱李月華優秀教師”獎等。

    社會任職：
    研究方向：
  • 　　譜系示蹤與細胞命運可塑性
    研究工作：

  • 研究組主要利用基于同源重組酶系統的遺傳譜系示蹤技術，在哺乳動物體內進行細胞標記及追蹤來研究細胞起源及命運，揭示發育、疾病、再生過程中的細胞分化、增殖、衰老、死亡等細胞命運過程，并闡明細胞命運調控的分子機制，為相關疾病治療提供重要理論基礎和新的研究方向，解決了領域內多個重要科學問題，取得系統性原創成果。代表性研究工作發表在Cell、Nature、Science等國際學術期刊，其中發現哺乳動物新生期心臟具有重新生成冠狀動脈的能力的成果入選“中國科學十大進展”;創建的譜系示蹤新技術解決了近20年來國際心血管領域內關于心臟干細胞與心肌再生的爭議問題;建立了雙重組酶介導的遺傳學技術和鄰近細胞遺傳學技術，從全新的角度揭示了器官發育與修復再生的調控機制。目前，我們的研究主要包括以下幾個方面：

    1、建立和發展譜系示蹤及遺傳操作新技術，實現哺乳動物體內更為精準、高效地遺傳示蹤和操作，揭示器官發育與組織再生過程中細胞分化、增殖、衰老、死亡等過程，并闡明其遺傳與表觀遺傳調控機制。

    2、建立鄰近細胞遺傳操作新技術，深入解析哺乳動物體內細胞-細胞交流過程，探索體內細胞微環境對干細胞命運調控的機理，為促進體內干細胞有效擴增和誘導分化提供理論基礎。

    3、探索異種器官再造技術，致力于實現重要器官的異種再造，研究成果將來可以為人類器官再造和移植奠定重要理論基礎和技術平臺。

    實驗室的長遠目標是實現器官原位再生和異體器官再造，為相關疾病治療提供新思路和新策略。


    　　研究組朝氣蓬勃，積極向上，團結進取，學術氣氛活躍，致力于成為 “嚴謹、團結、創新”的譜系示蹤與細胞命運研究團隊。近幾年來，研究組每年都有學生獲得國家獎學金、中科院院長獎、優秀畢業生、優秀博士論文等，培養的多位學生已赴國外頂尖學府(如哈佛大學等)從事博士后研究，或已在國內知名大學和科研院所任獨立PI(如復旦大學、同濟大學、西湖大學、上海科技大學、中科院藥物所等)。

    承擔科研項目情況：
    代表論著：

  • 2024

    1. Zhao H, Liu Z, Chen H, Han M, Zhang M, Liu K, Jin H, Liu X, Shi M, Pu W, Werner M, Meister M, Kauschke S, Sun R, Wang J, Shen R, Wang Q, Ma X, Thors J,?Zhou B*. Identifying specific functional roles for senescence across cell types.?Cell?2024, doi.org/10.1016/j.cell.2024.09.021
    2. Liu K, Meng X, Liu Z, Tang M, Lv Z, Huang X, Jin H, Han X, Liu X, Pu W, Zhu H,?Zhou B*. Tracing the origin of alveolar stem cells in lung repair and regeneration.?Cell?2024;187:2428-2445.
    3. Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, Zhao H, Xi Y, Sui P, Vaughan A, Gillich A,?Zhou B*. Alveolar regeneration by airway secretory cell-derived p63+ progenitors. 2024?Cell Stem Cell?doi.org/10.1016/j.stem.2024.08.005
    4. Guo W, Zhang X, Li L, Shao P, Liang C, Zhang H, Liu K, Wang S, Peng Y, Luo J, Ju Y, De Marzo A*, Yu C*, Chen L*,?Zhou B*, Gao D*. JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination.?Nat Genet?2024 in press
    5. Liu K, Zhang S, Meng X, Li H, Zhu J, Wang E, Tang M, Zhang M,?Zhou B*, Wang L*. Intercellular genetic tracing by alternative synthetic Notch signaling.?Cell Discov?2024 in press
    6. Li Y, Liu Z, Han X, Liang F, Zhang Q, Huang X, Shi X, Huo H, Han M, Liu X, Zhu H, He L, Shen L, Hu X, Wang J, Wang Q, Smart N,?Zhou B*, He B*.?Dynamics of Endothelial Cell Generation and Turnover in Arteries during Homeostasis and Diseases.?Circulation?2024;149:135-154.
    7. Zhang M, Lui K*,?Zhou B*. Application of New Lineage Tracing Techniques in Cardiovascular Development and Physiology.?Circ Res?2024;134:445-458.
    8. Yang G*, He Q, Guo X, Li RY, Lin J, Lang Y, Tao W, Liu W, Lin H, Xing S, Qi Y, Xie Z, Han JJ,?Zhou B*, Teng Y*, Yang X*. Identification of the metaphyseal skeletal stem cell building trabecular bone.?Sci Adv?2024;10:eadl2238.
    9. Shi M, Li J, Liu X, Liu K, Pu W, Weng W, Zhang S, Zhao H, Lui K,?Zhou B*. The robust, high-throughput, and temporally regulated roxCre and loxCre reporting systems for genetic modifications in vivo.?ELife?2024 doi.org/10.7554/eLife.97717.1

    2023

    1. Pu W, Zhu H, Zhang M, Pikiolek M, Ercan C, Li J, Huang X, Han X, Zhang Z, Lv Z, Li Y, Liu K, He L, Liu X, Heim MH, Terracciano L, Tchorz JS*, Zhou B*. Bipotent transitional liver progenitor cells contribute to liver regeneration.?Nat Genet?2023;55(4):651-664. (Cover Story)
    2. Han M, Z L, Liu L, Huang X, Wang H, Pu W, Wang E, Liu X, Li Y, He L, Li X, Wu J, Qiu L, She R, Wang Q, Ji Y, Ardehali R, Shu Q, Lui KO, Wang L, Zhou B*. Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis. Nat Genet 2023;55(4):665-678.
    3. Liu K*, Jin H, Zhang S, Tang M, Meng X, Li Y, Pu W, Lui K, Zhou B*. Intercellular genetic tracing shows the lack of hematopoietic specification from cardiac endothelium in the developing heart. Dev Cell 2023;58(16):1502-1512.
    4. Wu J, Zhao H, Tao Y, Yang C, Yang Y, Zhou B*, Zhao Y*. Improved Factor Combination for In ?Vivo Reprogramming of Cardiac Myofibroblast to Cardiomyocyte-Like Cell With Dual Recombinase Tracing. Circulation 2023;148:1728-1731.
    5. Zhang S, Zhang Q, Liu Z, Liu K, He L, Lui KO, Wang L*, Zhou B*. Genetic dissection of intercellular interactions in?vivo by membrane-permeable protein. PNAS?2023;120(1):e2120582120.
    6. Liu K, Tang M, Xu W, Meng X, Jin H, Han M, Pu J, Li Y, Jiao F, Sun R, Shen R, Lui K, Lu L*, Zhou B*. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo. PNAS 2013;120(25):e2207210120.
    7. Liu X, Weng W, He L*, Zhou B*. Genetic recording of in vivo cell proliferation by ProTracer. Nat Protoc 2023;18:2349-2373. Cover Story.
    8. Zhao H, Huang X, Liu Z, Lai L, Sun R, Shen R, Li Y, He L, Pu W, Lv Z, Li Y, Han X, Liu X, Zhou B*. Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas. Cell Discov?2023;9:1.
    9. Zhang M, Pu W, Li J, Han M, Han X, Zhang Z, Lv Z, Smart N, Wang L*, Zhou B*. Coronary vessels contribute to de novo endocardial cells in the endocardium-depleted heart. Cell Discov?2023;9:9

    2022

    1. Zhang S, Zhao H, Liu Z, Liu K, Zhu H, Pu W, He L, Wang R, Zhou B*. Monitoring of cell-cell communication and contact history in mammals. Science 2022;378(6623): eabo5503.
    2. Pu W, Zhang M, Liu X, He L, Li J, Han X, Lui KO, He B, Zhou B*. Genetic Proliferation Tracing Reveals a Rapid Cell Cycle Withdrawal in Preadolescent Cardiomyocytes. Circulation 2022;145:410-412.
    3. Han M, Liu Z, He L, Li X, Liu L, Huang X, Zhang M, Yan Y, Lui KO, Zhou B*. Dual Genetic Lineage Tracing Reveals Capillary to Artery Formation in the Adult Heart. Circulation 2022;145:1179-1181.
    4. Tang J, Zhu H, Tian X, Wang H, Liu S, Liu K, Zhao H, He L, Huang X, Feng Z, Ding Z, Long B, Yan Y, Smart N, Gong H, Luo Q, Zhou B*. Extension of Endocardium-Derived Vessels Generate Coronary Arteries in Neonates. Circ Res 2022;130:352-365. (Cover story)
    5. Jin H, Liu K, Huang X, Huo H, Mou J, Qiao Z, He B, Zhou B*. Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circ Res 2022;130:1682-1697. (Cover story)
    6. Liu K, Jin H, Tang M, Zhang S, Tian X, Zhang M, Han X, Liu X, Tang J, Pu W, Li Y, He L, Yang Z, Lui K, Zhou B*. Lineage tracing clarifies the cellular origin of tissue resident macrophages in the developing heart. J Cell Biol 2022;221:e202108093.
    7. Wang H, He L, Li Y, Pu W, Zhang S, Han X, Lui K, Zhou B*. Dual recombinases mediate synchronized lineage tracing and cell subset ablation in vivo. J Bio Chem 2022;298:101965.

    2021

    1. He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang Q-D, Ji Y, Tchorz JS, Zhou B*. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science 2021;6532:eabc4346.
    2. Han X, Zhang Z, He L, Zhu H, Li Y, Pu W, Han M, Zhao H, Liu K, Li Y, Huang X, Zhang M, Jin H, Lv Z, Tang J, Wang J, Sun R, Fei J, Tian X, Duan S, Wang Q, Wang L, He B, Zhou B*. A suite of new Dre-recombinase drivers markedly expands the ability to perform intersection genetic targeting. Cell Stem Cell 2021;28:1-17.
    3. Zhao H, Huang X, Liu Z, Pu W, Lv Z, He L, Li Y, Zhou Q, Lui KO, Zhou B*. Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nat Metab 2021;3:352-365.
    4. Wang H, Zhao H, Zhu H, Li Y, Tang J, Li Y, Zhou B*. Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis. Circ Res 2021;128:133-135.
    5. Tian X*, Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution. J Biol Chem 2021;296: S0021-9258(21)00285-4.
    6. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B*. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021;592:606-610.
    7. Liu X, Pu W, He L, Li Y, Zhao H, Li Y, Liu K, Huang X, Weng W, Wang Q-D, Shen L, Zhong T, Sun K, Ardehali R, He B*,?Zhou B*. Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle.?Nat Commun?2021;12(1):5784.
    8. Jin H, Liu K, Tang J, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi K, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L,?Zhou B*.?Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.?Nat Commun?2021; 12(1): 2863.
    9. Zhang S, Li Y, Huang X, Liu K, Wang QD, Chen AF, Sun K, Lui KO,?Zhou B*. Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis.?Circulation?2021;144:2004-2020.
    10. Li Y, Zhu H, Zhang Q, Han X, Zhang Z, Shen L, Wang L, Lui KO, He B,?Zhou B*. Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque.?Cell Discov?2021;7:111.
    11. Tang J, Zhu H, Liu S, Wang H, Huang X, Yan Y, Wang L,?Zhou B*. Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury.?Cell Discov?2021;7.
    12. Tian X,?Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution.?J Biol Chem?2021;296:100509.
    13. Weng W, Liu X, Lui KO,?Zhou B*. Harnessing orthogonal recombinases to decipher cell fate with enhanced precision.?Trends Cell Biol?2021S0962-8924(21)00186.
    14. Zhao H, Lui KO,?Zhou B*. Pancreatic beta cell neogenesis: Debates and updates.?Cell Metab?2021;33:2105-2107.

    2020

    1. Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L, Gao D, Zhou B*. Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020;26:81-96.e4.
    2. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B*. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020;54:593-607.e5.
    3. Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J*. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell 2020;52:617-630.e6.
    4. He L, Nguyen NB, Ardehali R, Zhou B*. Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. Circulation 2020;142:275-291.
    5. Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu YT, Xu C, Wei Y, Ding Q, Song BL, Huang H, Zhou B*. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation 2020;141:67-79.
    6. Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lyu A, Lazarus M, Breyer RM, Yu Y*. DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation 2020;141:655-666.
    7. Liu K, Tang M, Jin H, Liu Q, He L, Zhu H, Liu X, Han X, Li Y, Zhang L, Tang J, Pu W, Lv Z, Wang H, Ji H, Zhou B*. Triple-cell lineage tracing by a dual reporter on a single allele. J Biol Chem 2020;295:690-700.
    8. Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B*, Lui KO*. Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics 2020;10:8018-8035.
    9. Li H, Zhang Q, Gu Y, Wu Y, Wang Y, Wang L, Feng S, Hu Y, Zheng Y, Li Y, Ye H, Zhou B, Lin L, Liu M, Yang H, Li D*. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A 2020;117:33426-33435.
    10. Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, Zhu T, Ma F, Tang Q, Zhou B*, Zhu J*. Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier. Science Advances 2020;6:eaay8627.
    11. Han M, Zhou B*. Sox17 and Coronary Arteriogenesis in Development. Circ Res 2020;127:1381-1383.
    12. Pu W, Han X, Zhang M, Li Y, Huang X, He L, Zhou B*. Resident endothelial cells generate hepatocytes through cell fusion in adult mouse liver. J Genet Genomics 2020;47:225-228.
    13. Yue Y, Zong W, Li X, Li J, Zhang Y, Wu R, Liu Y, Cui J, Wang Q, Bian Y, Yu X, Liu Y, Tan G, Zhang Y, Zhao G, Zhou B, Chen L, Xiao W, Cheng H, He A*. Long-term, in toto live imaging of cardiomyocyte behaviour during mouse ventricle chamber formation at single-cell resolution. Nat Cell Biol 2020;22:332-340.
    14. Li Y, Feng J, Song S, Li H, Yang H, Zhou B, Li Y, Yue Z, Lian H, Liu L, Hu S*, Nie Y*. gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration. Circulation 2020;142:967-982.
    15. Liu K, Jin H, Zhou B*. Genetic lineage tracing with multiple DNA recombinases: A user’s guide for conducting more precise cell fate mapping studies. J Biol Chem 2020;295:6413-6424.
    16. Tian X*, He L, Liu K, Pu W, Zhao H, Li Y, Liu X, Tang M, Sun R, Fei J, Ji Y, Qiao Z, Lui KO, Zhou B*. Generation of a self-cleaved inducible Cre recombinase for efficient temporal genetic manipulation. EMBO J 2020;39:e102675.
    17. Yin Q, Wang H, Li N, Ding Y, Xie Z, Jin L, Li Y, Wang Q, Liu X, Xu L, Li Q, Ma Y, Cheng Y, Wang K, Zhong C, Yu Q, Tang W, Chen W, Yang W, Zhang F, Ding C, Bao L, Zhou B, Hu P, Li J*. Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1. Cell Res 2020;30:133-145.
    18. Gillich A, Zhang F, Farmer CG, Travaglini KJ, Tan SY, Gu M, Zhou B, Feinstein JA, Krasnow MA*, Metzger RJ*. Capillary cell-type specialization in the alveolus. Nature 2020;586（7831）:785-789.
    19. Liu K, Tang M, Liu Q, Han X, Jin H, Zhu H, Li Y, He L, Ji H, Zhou B*. Bi-directional differentiation of single bronchioalveolar stem cells during lung repair. Cell Discov 2020;6:1.
    20. Chu Q, Jiang H, Zhang L, Zhu D, Yin Q, Zhang H, Zhou B, Zhou W, Yue Z, Lian H, Liu L, Nie Y, Hu S*. CACCT: An Automated Tool of Detecting Complicated Cardiac Malformations in Mouse Models. Adv Sci (Weinh) 2020;7:1903592.
    21. Pu W, Han X, He L, Li Y, Huang X, Zhang M, Lv Z, Yu W, Wang QD, Cai D, Wang J, Sun R, Fei J, Ji Y, Nie Y, Zhou B*. A genetic system for tissue-specific inhibition of cell proliferation. Development 2020;147:dev183830.
    22. Brulois K, Rajaraman A, Szade A, Nordling S, Bogoslowski A, Dermadi D, Rahman M, Kiefel H, O’Hara E, Koning JJ, Kawashima H, Zhou B, Vestweber D, Red-Horse K, Mebius RE, Adams RH, Kubes P, Pan J, Butcher EC*. A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nat Commun 2020;11:3798.

    2019

    1. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H*, Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet 2019;51:728-738.
    2. He L, Han M, Zhang Z, Li Y, Huang X, Liu X, Pu W, Zhao H, Wang Q, Nie Y, Zhou B*. Reassessment of c-Kit Cells for Cardiomyocyte Contribution in Adult Heart. Circulation 2019;140:164-166.
    3. Li Y, Lv Z, He L, Huang X, Zhang S, Zhao H, Pu W, Li Y, Yu W, Zhang L, Liu X, Liu K, Tang J, Tian X, Wang Q-D, Lui KO, Zhou B*. Genetic Tracing Identifies Early Segregation of the Cardiomyocyte and Nonmyocyte Lineages. Circ Res 2019;125:343-355.
    4. Zhang X, Zhang H, Xu C, Li X, Li M, Wu X, Pu W, Zhou B, Wang H, Li D, Ding Q, Ying H, Wang H, Zhang H*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun 2019;10:4158.
    5. Yu W, Ma X, Xu J, Heumüller AW, Fei Z, Feng X, Wang X, Liu K, Li J, Cui G, Peng G, Ji H, Li J, Jing N, Song H, Lin Z, Zhao Y, Wang Z, Zhou B*, Zhang L*. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet 2019;15:e1007977.
    6. Ni Z, Deng J, Potter CMF, Nowak WN, Gu W, Zhang Z, Chen T, Chen Q, Hu Y, Zhou B, Xu Q, Zhang L*. Recipient c-Kit Lineage Cells Repopulate Smooth Muscle Cells of Transplant Arteriosclerosis in Mouse Models. Circ Res 2019;125:223-241.
    7. Han X, Wang Y, Pu W, Huang X, Qiu L, Li Y, Yu W, Zhao H, Liu X, He L, Zhang L, Ji Y, Lu J, Lui KO, Zhou B*. Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration. Stem Cell Reports 2019;12:624-638.
    8. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT*. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun 2019;10:4907.
    9. Chen Q, Liu Y, Jeong HW, Stehling M, Dinh VV, Zhou B, Adams RH*. Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury. Cell Stem Cell 2019;25:768-783.e6.
    10. Wei X, Guo J, Li Q, Jia Q, Jing Q, Li Y, Zhou B, Chen J, Gao S, Zhang X, Jia M, Niu C, Yang W, Zhi X, Wang X, Yu D, Bai L, Wang L, Na J, Zou Y, Zhang J, Zhang S, Meng D*. Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells. Sci Adv 2019;5:eaau7887.
    11. Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H, Guo W, Yang X. Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis. Cell Stem Cell 2019
    12. Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B*, Zhang H*. CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Circulation 2019;139:2495-2498.

    2018

    1. Li Y, He L, Huang X, Issa Bhaloo S, Zhao H, Zhang S, Pu W, Tian X, Li Y, Liu Q, Yu W, Zhang L, Liu X, Liu K, Tang J, Zhang H, Cai D, Adams RH, Xu Q, Lui KO, Zhou B*. Genetic Lineage Tracing of Non-Myocyte Population by Dual Recombinases. Circulation 2018;138:793-805.
    2. Tang J, Li Y, Huang X, He L, Zhang L, Wang H, Yu W, Pu W, Tian X, Nie Y, Hu S, Wang Q-D, Lui KO, Zhou B*. Fate Mapping of Sca1 Cardiac Progenitor Cells in the Adult Mouse Heart. Circulation 2018;138:2967-2969.
    3. Zhang H, Lui KO, Zhou B*. Endocardial Cell Plasticity in Cardiac Development, Diseases and Regeneration. Circ Res 2018;122:774-789.
    4. Tang J, Zhang H, He L, Huang X, Li Y, Pu W, Yu W, Zhang L, Cai D, Lui KO, Zhou B*. Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart. Circ Res 2018;122:984-993.
    5. Pu W, He L, Han X, Tian X, Li Y, Zhang H, Liu Q, Huang X, Zhang L, Wang QD, Yu Z, Yang X, Smart N, Zhou B*. Genetic Targeting of Organ-Specific Blood Vessels. Circ Res 2018;123:86-99.
    6. Zhang L, Issa Bhaloo S, Chen T, Zhou B*, Xu Q*. Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis. Circ Res 2018;122:1608-1624.
    7. Zhou B, Wu SM*. Reassessment of c-Kit in Cardiac Cells: A Complex Interplay Between Expression, Fate, and Function. Circ Res 2018;123:9-11.
    8. Zhao ZA, Han X, Lei W, Li J, Yang Z, Wu J, Yao M, Lu XA, He L, Chen Y, Zhou B, Hu S*. Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts. Circ Res 2018;123:266-287.
    9. Li Y, Zhao H, Huang X, Tang J, Zhang S, Li Y, Liu X, He L, Ju Z, Lui KO, Zhou B*. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res 2018;28:775-778.
    10. Liu K, Yu W, Tang M, Tang J, Liu X, Liu Q, Li Y, He L, Zhang L, Evans SM, Tian X, Lui KO, Zhou B*. A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development 2018;145:dev167775.

    2017

    1. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nat Med 2017;23:1488-1498.
    2. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial cells mediate cardiac neovascularization after injury. J Clin Invest 2017;127:2968-2981.
    3. Sun XN, Li C, Liu Y, Du LJ, Zeng MR, Zheng XJ, Zhang WC, Liu Y, Zhu M, Kong D, Zhou L, Lu L, Shen ZX, Yi Y, Du L, Qin M, Liu X, Hua Z, Sun S, Yin H, Zhou B, Yu Y, Zhang Z, Duan SZ*. T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma. Circ Res 2017;120:1584-1597.
    4. Zangi L, Oliveira MS, Ye LY, Ma Q, Sultana N, Hadas Y, Chepurko E, Sp？ter D, Zhou B, Chew WL, Ebina W, Abrial M, Wang QD, Pu WT, Chien KR*. Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury. Circulation 2017;135:59-72.
    5. Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang Q-D, Wu SM, Pu WT, Anderson RH, Zhou B*. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun 2017;8:759.
    6. Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Res 2017;27:1157-1177.
    7. Wang WE, Li L, Xia X, Fu W, Liao Q, Lan C, Yang D, Chen H, Yue R, Zeng C, Zhou L, Zhou B, Duan DD, Chen X, Houser SR, Zeng C*. Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation 2017;136:834-848.
    8. Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH*. Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol 2017;27:386-401.
    9. Han X, Yu H, Huang D, Xu Y, Saadatpour A, Li X, Wang L, Yu J, Pinello L, Lai S, Jiang M, Tian X, Zhang F, Cen Y, Fujiwara Y, Zhu W, Zhou B, Zhou T, Ouyang H, Wang J, Yuan GC, Duan S, Orkin SH, Guo G*. A molecular roadmap for induced multi-lineage trans-differentiation of fibroblasts by chemical combinations. Cell Res 2017;27:386-401.
    10. He L, Zhou B*. Cardiomyocyte proliferation: remove brakes and push accelerators. Cell Res 2017;27:959-960.

    2016

    1. Zhang H, Pu W, Tian X, Huang X, He L, Liu Q, Li Y, Zhang L, He L, Liu K, Gillich A, Zhou B*. Genetic lineage tracing identifies endocardial origin of liver vasculature. Nat Genet 2016;48:537-543.
    2. Zhang H, Pu W, Liu Q, He L, Huang X, Tian X, Zhang L, Nie Y, Hu S, Lui KO, Zhou B*. Endocardium Contributes to Cardiac Fat. Circ Res 2016;118:254-265.
    3. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B*. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res 2016;118:1880-1893.
    4. Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y*. Thromboxane Governs the Differentiation of Adipose-Derived Stromal Cells Toward Endothelial Cells In Vitro and In Vivo. Circ Res 2016;118:1194-1207.
    5. Li G, Xu A, Sim S, Priest JR, Tian X, Khan T, Quertermous T, Zhou B, Tsao PS, Quake SR, Wu SM*. Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells. Dev Cell 2016;39:491-507.
    6. Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B*. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun 2016;7:13369.
    7. Liu Q, Yang R, Huang X, Zhang H, He L, Zhang L, Tian X, Nie Y, Hu S, Yan Y, Zhang L, Qiao Z, Wang QD, Lui KO, Zhou B*. Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes. Cell Res 2016;26:119-130.
    8. Xie C, Zhang YP, Song L, Luo J, Qi W, Hu J, Lu D, Yang Z, Zhang J, Xiao J, Zhou B, Du JL, Jing N, Liu Y, Wang Y, Li BL, Song BL, Yan Y*. Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Res 2016;26:1099-1111.
    9. He L, Liu Q, Hu T, Huang X, Zhang H, Tian X, Yan Y, Wang L, Huang Y, Miquerol L, Wythe JD, Zhou B*. Genetic lineage tracing discloses arteriogenesis as the main mechanism for collateral growth in the mouse heart. Cardiovasc Res 2016;109:419-430.
    10. Yu W, Huang X, Tian X, Zhang H, He L, Wang Y, Nie Y, Hu S, Lin Z, Zhou B, Pu W, Lui KO, Zhou B*. GATA4 regulates Fgf16 to promote heart repair after injury. Development 2016;143:936-949.
    11. Chen Q, Zhang H, Liu Y, Adams S, Eilken H, Stehling M, Corada M, Dejana E, Zhou B, Adams RH*. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. Nat Commun 2016;7:12422.
    12. Mondor I, Jorquera A, Sene C, Adriouch S, Adams RH, Zhou B, Wienert S, Klauschen F, Bajénoff M*. Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling. Immunity 2016;45:877-888.

    2015

    1. Liu Q, Huang X, Zhang H, Tian X, He L, Yang R, Yan Y, Wang QD, Gillich A, Zhou B*. c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair. Nat Med 2015;21:866-868.
    2. Tian X, Pu WT*, Zhou B*. Cellular Origin and Developmental Program of Coronary Angiogenesis. Circ Res 2015;116:515-530.
    3. Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y*. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-beta1 signaling. J Clin Invest 2015;125:1228-1242.
    4. Wei K, Serpooshan V, Hurtado C, Diez-Cunado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature 2015;525:479-485.
    5. Liu Q, Hu T, He L, Huang X, Tian X, Zhang H, He L, Pu W, Zhang L, Sun H, Fang J, Yu Y, Duan S, Hu C, Hui L, Zhang H, Quertermous T, Xu Q, Red-Horse K, Wythe JD, Zhou B*. Genetic targeting of sprouting angiogenesis using Apln-CreER. Nat Commun 2015;6:6020.
    6. Zhang WC, Zheng XJ, Du LJ, Sun JY, Shen ZX, Shi C, Sun S, Zhang Z, Chen XQ, Qin M, Liu X, Tao J, Jia L, Fan HY, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan SZ*. High salt primes a specific activation state of macrophages, M(Na). Cell Res 2015;25:893-910.
    7. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ*. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest 2015;125:4122-4134.

    2014

    1. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Yan Y, Yang X, Zhong TP, Pu WT, Zhou B*. De novo formation of a distinct coronary vascular population in neonatal heart. Science 2014;345:90-94.
    2. Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B*. Epicardium-to-fat transition in injured heart. Cell Res 2014;24:1367-1369.
    3. Yang G, Zhu L, Hou N, Lan Y, Wu XM, Zhou B, Teng Y, Yang X*. Osteogenic fate of hypertrophic chondrocytes. Cell Res 2014;24:1266-1269.
    4. Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP*. Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nat Cell Biol 2014;16:841-851.
    5. Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K*. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. J Clin Invest 2014;124:4899-4914.
    6. Zhang H, von Gise A, Liu Q, Hu T, Tian X, He L, Pu W, Huang X, He L, Cai CL, Camargo FD, Pu WT, Zhou B*. Yap1 Is Required for Endothelial to Mesenchymal Transition of the Atrioventricular Cushion. J Biol Chem 2014;289:18681-18692.
    7. Lin Z, von Gise A, Zhou P, Gu F, Ma Q, Jiang J, Yau AL, Buck JN, Gouin KA, van Gorp PR, Zhou B, Chen J, Seidman JG, Wang DZ, Pu WT*. Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model. Circ Res 2014;115:354-363.

    2013

    1. Tian X, Hu T, Zhang H, He L, Huang X, Liu Q, Yu W, He L, Yang Z, Zhang Z, Zhong TP, Yang X, Yang Z, Yan Y, Baldini A, Sun Y, Lu J, Schwartz RJ, Evans SM, Gittenberger-de Groot AC, Red-Horse K, Zhou B*. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res 2013;23:1075-1090.
    2. Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT*. Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A 2013;110:15395-15400.

    2012

    1. Zhou B*, Pu WT*. Genetic Cre-loxP Assessment of Epicardial Cell Fate Using Wt1-Driven Cre Alleles. Circ Res 2012;111:e276-e280.
    2. von Gise A, Lin Z, Schlegelmilch K, Honor LB, Pan GM, Buck JN, Ma Q, Ishiwata T, Zhou B, Camargo FD, Pu WT*. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A 2012;109:2394-2399.
    3. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ*. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res 2012;110:818-830.
    4. Wu KH, Han ZC, Mo XM, Zhou B*. Cell delivery in cardiac regenerative therapy. Ageing Res Rev 2012;11:32-40.

    2011 and before (Postdoc)

    1. Zhou B*, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT*. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest 2011;121:1894-1904.
    2. Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X*. A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest 2011;121:1585-1595.
    3. Zhou B, von Gise A, Ma Q, Hu YW, Pu WT*. Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 2010;338:251-261.
    4. Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 2009;119:1462-1476.
    5. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD*. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 2008;103:1393-1401.
    6. Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT*. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 2008;454:109-113.
    獲獎及榮譽：
    研究組成員：

  • 合影

free性丰满69性欧美| 国产日韩视频| 日韩无码电影| 美女搞黄网站| 国产黄色一级片| 欧美性爱一区二区三区| 精品人妻无码| 免费一级a| 99国产在线| 亚洲黄色大片| 欧美黄色一区| 久久嫩草精品久久久久| 无码精品一区二区三区在线播放| 亚洲永久无码7777KKK| 人妻体体内射精一区二区| 女人高潮特级毛片| 人妻无码中文字幕| 欧美肏屄视频| 午夜操一操| 久久婷婷五月| 欧美性爱在线观看| 色欲av永久无码精品无码蜜桃| 国产精品一区二区不卡| 玖玖成人| 一区二区三区视频| 日本色色网| 国产成人精品视频| 大香蕉久久| 男子大捧一进一出视频| 国产又粗又大又爽| 天天干干| 久草超碰| 人妻一二三区| 精品免费视频| 巨大黑人极品VIDEOS精品| 伊人免费视频| 中文字幕一区二区三区人妻在线视频 | 国产亚洲色婷婷久久99精品91| 久久久一区二区三区| 亚洲视频三区| 人人看人人干|