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2001年獲武漢大學學士學位，2007年獲中科院上海生科院健康科學研究所博士學位，2008至2013年在美國安德森癌癥中心(MD Anderson Cancer Center)做博士后研究，并成為奧德賽學者(Odyssey Fellow)。2013年8月起擔任中科院生物化學與細胞生物學研究所研究員，研究組長，博士生導師。

腫瘤細胞的代謝重塑在腫瘤發生發展中發揮至關重要的作用。腫瘤細胞響應功能基因突變和多變的環境因素，如營養物、生長因子、免疫細胞和飲食等，主動調節代謝途徑的通量、甚至改變特定途徑的走向，以滿足腫瘤細胞無限增殖所需的生物大分子合成原料、能量以及氧化還原穩態。此外，特定功能基因的突變還會導致一些有活性的代謝中間產物異常累積，進而通過調控基因的表達和信號轉導的激活加速腫瘤生長，并促進腫瘤轉移和治療抵抗。只有充分解析這些過程才能發現腫瘤代謝重塑的關鍵節點，并轉化為新型癌癥治療手段。

1. 腫瘤細胞的代謝重塑

2. 腫瘤免疫微環境的代謝調控

3. 代謝物豐度感知

（*Corresponding author）

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