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1998年本科畢業(yè)于南開大學，2003年畢業(yè)于中國科學院上海生命科學研究院生物化學與細胞生物學研究所，獲理學博士學位。2003-2012年先后在美國Scripps研究所和哈佛大學公共衛(wèi)生學院進行博士后研究并受美國白血病淋巴瘤協(xié)會資助，2009年入選哈佛大學公共衛(wèi)生學院Yerby Fellow，2012年獲聘康納爾大學和紐約州立大學布法羅分校Tenure Track助理教授職位，2012年8月加入中國科學院生物化學與細胞生物學研究所，任研究員、研究組長、博士生導師。獲國家自然科學基金委杰出青年科學基金、優(yōu)秀青年基金，國家海外高層次人才計劃（青年類）資助，主持國家自然科學基金委重大項目、重點項目，國家重點基礎研究發(fā)展計劃（973計劃）課題，中國科學院戰(zhàn)略性先導科技專項課題等。擔任國際華人骨研學會（ICMRS）董事會董事、中國生物工程學會轉化醫(yī)學專業(yè)委員會副主任委員、中華醫(yī)學會骨科學分會組織工程與再生醫(yī)學青年組組長、中國骨質疏松與骨礦鹽疾病分會基礎組常委、中國老年醫(yī)學會骨質疏松分會創(chuàng)新與轉化專委會常委等。

運動系統(tǒng)功能性干細胞包括骨膜干細胞、生長板干細胞、骨髓間充質干細胞、關節(jié)軟骨干細胞、肌腱干細胞、肌肉干細胞等。運動系統(tǒng)功能性干細胞具有多能性和自我更新能力，在組織發(fā)育、穩(wěn)態(tài)維持、疾病和衰老等過程中起重要作用。運動系統(tǒng)功能性干細胞向不同組織細胞的分化受到多種遺傳因素和表觀遺傳因素的影響，并受多種信號途徑調控。調控因素的異常將導致多種疾病，包括先天性發(fā)育畸形、運動系統(tǒng)退行性疾病如骨質疏松癥、骨性關節(jié)炎以及肌腱疾病等。

研究組通過綜合運用空間轉錄組測序、單細胞測序、譜系示蹤等多種研究手段來鑒定運動系統(tǒng)新型干細胞。已建立了間充質干細胞向多種細胞分化的體外高通量篩選系統(tǒng)，研究干細胞增殖分化的分子機制及多種相關疾病的致病機理，并通過分子遺傳學手段建立了骨骼早衰、力學感知失調、關鍵干細胞穩(wěn)態(tài)失調等多種動物模型，模擬骨質疏松、骨關節(jié)炎、骨折等常見骨科疾病，圍繞骨骼系統(tǒng)的受力、衰老與功能性干/前體細胞等關鍵科學問題，在骨科基礎研究領域取得了多項創(chuàng)新性研究成果。

實驗室近期研究方向包括：

1）鑒定運動系統(tǒng)功能性干細胞，研究其參與損傷修復的命運轉歸和調控機制。

2）研究機械力對間充質干細胞/運動系統(tǒng)功能性干細胞的調控及其分子機制。

3）研究間充質干細胞/運動系統(tǒng)功能性干細胞的衰老與疾病的關聯(lián)及分子機制。

1. Ren Q, Xing W, Jiang B, Feng H, Hu X, Suo J, Wang L*, Zou W*. (2025) Tenascin-C promotes bone regeneration via inflammatory macrophages. Cell Death and Differentiation. 32(4): 763-775.
2. Wang L^#*, Ren Q^#, Chen S^#, Lou L, Hu X, Xing W, Suo J, Sun J, Greenblatt M, Feng H, Zou W*. (2025) Piezo1 balances the osteogenic-tenogenic plasticity of periosteal progenitor cells through the YAP pathway. Cell Reports. 44(5): 115630.
3. Xing W^#, Feng H^#*, Jiang B, Gao B, Liu J, Xie Z, Zhang Y, Hu X, Sun J, Greenblatt M, Zhou B*, Zou W*. (2024) Identification of a Periosteal Itm2a-expressing Skeletal Stem Cell Contributing to Bone Fracture Healing. Journal of Clinical Investigation. 134(17): e176528.
4. Liu Y^#, Tang X^#, Shu H^#, Zou W*, Zhou B*. (2024) Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood. Developmental Cell. 59(9): 1192-1209.e6.
5. Wang L#, You X#, Ruan D#, Shao R, Dai H, Shen W, Xu G, Liu W, Zou W*. (2022) TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 13(1):4709.
6. Gao B#, Jiang B#, Xing W, Xie Z, Luo Z*, Zou W*. (2022) Discovery and application of postnatal nucleus pulposus progenitors essential for intervertebral disc homeostasis and degeneration. Advanced Science. 9(13): e2104888.
7. Suo J #, Zou S#, Wang J#, Han Y, Zhang L, Lv C, Jiang B, Ren Q, Chen L, Yang L, Ji P, Zheng X*, Hu P*, Zou W*. (2022) The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research. 10(1): 31.
8. Wang L, You X, Zhang L, Zhang C, Zou W*. (2022) Mechanical regulation of bone remodeling. Bone Research. 10(1): 16.
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10. Feng H#, Xing W#, Han W#, Sun J, Kong M, Gao B, Yang Y, Yin Z, Chen X, Zhao Y, Bi Q, Zou W*. (2020) Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. Journal of Clinical Investigation. 130(12): 6354-6365.
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12. Suo J#, Feng X#, Li J, Wang J, Wang Z*, Zhang L*, Zou W*. (2020) VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited RUNX2 transcription. Science Advances. 6(43): eaba4147.
13. Wang L, You X, Lotinun S, Zhang L, Wu N, Zou W*. (2020) Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature Communications. 11: 282.
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15. Bai M, Han Y, Wu Yu, Liao J, Li L, Wang L, Li Q, Xing W, Chen L, Zou W*, Li J*. (2019) Targeted genetic screening in mice through haploid embryonic stem cells identifies critical genes in bone development. PLoS Biology. 17: e3000350.
16. Wang L, Niu N, Li L, Shao R, Ouyang H, Zou W*. (2018) H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 16: e2006522.
17. Han Y, You X, Xing W, Zhang Z, Zou W*. (2018) Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Research. May 24; 6:16.
18. Sun J, Ermann J, Niu N, Yan G, Yang Y, Shi Y, Zou W*. (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Research. Apr 26; 6:14.
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20. Xu Z, Greenblatt M, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher L, Zou W*. (2017) SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts. Nature Communications 8:14570.
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