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1999年畢業(yè)于清華大學(xué)生物科學(xué)與技術(shù)系，獲得生物學(xué)學(xué)士學(xué)位；2005年1月獲清華大學(xué)生物物理學(xué)博士學(xué)位；2005年—2012年在美國密西根大學(xué)醫(yī)學(xué)院生物化學(xué)系從事博士后研究。2012年起任中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所研究員，研究組長，博士生導(dǎo)師。兼任上海科技大學(xué)特聘教授、國科大杭州高等研究院雙聘研究員。在Nature、Nat Cell Biol、Mol Cell、Cell Res、Nat Commun、Nucleic Acids Res等學(xué)術(shù)期刊上發(fā)表通訊作者論文24篇。先后獲得中科院戰(zhàn)略先導(dǎo)項目、科技部重點研發(fā)計劃、自然科學(xué)基金委面上項目、上海市基礎(chǔ)研究特區(qū)計劃、上海市科委基礎(chǔ)重點項目等項目的支持。入選海外高層次人才引進(jìn)計劃（青年）、國家高層次人才特殊支持計劃科技創(chuàng)新領(lǐng)軍人才。四次獲得中國科學(xué)院優(yōu)秀導(dǎo)師獎（2016、2018、2020、2022年度）、兩次獲得中國科學(xué)院大學(xué)領(lǐng)雁銀獎（2021、2023年度）。目前擔(dān)任中國生物化學(xué)與分子生物學(xué)會理事、中國生物化學(xué)與分子生物學(xué)會基因?qū)I(yè)分會秘書長、上海市生物物理學(xué)會理事。

染色質(zhì)是真核生物遺傳信息的基本載體和信息編解碼的基本單元。染色質(zhì)的結(jié)構(gòu)和功能研究是破譯人類基因組“天書”的關(guān)鍵所在，也是闡明癌癥等重大疾病致病機(jī)理的重要抓手。染色質(zhì)的基本結(jié)構(gòu)單元是由組蛋白和DNA組成的核小體（nucleosome），多聚核小體進(jìn)一步折疊和堆積形成染色質(zhì)高級結(jié)構(gòu)。染色體結(jié)構(gòu)的動態(tài)變化和隨之而來的功能改變，有賴于DNA修飾、組蛋白化學(xué)修飾、染色質(zhì)重塑等多種表觀遺傳因子的協(xié)同調(diào)控。

本實驗室圍繞“染色質(zhì)調(diào)控”這一核心主題，從染色質(zhì)基本結(jié)構(gòu)單元和高級結(jié)構(gòu)兩個尺度入手，綜合運用多種結(jié)構(gòu)生物學(xué)、生物化學(xué)、生物物理、細(xì)胞生物學(xué)、生物信息學(xué)等技術(shù)手段，聚焦于多個重要的表觀遺傳調(diào)控復(fù)合物的結(jié)構(gòu)和功能研究，以闡明染色質(zhì)結(jié)構(gòu)的動態(tài)調(diào)控規(guī)律，推動特定表觀靶點的藥物設(shè)計。

實驗室研究主要包括以下兩個研究方向：

1.染色質(zhì)基本單元的調(diào)控機(jī)制研究：核小體是染色質(zhì)的基本結(jié)構(gòu)單元。實驗室致力于破解由組蛋白修飾酶復(fù)合物、DNA修飾酶、染色體重塑復(fù)合物等表觀遺傳因子所組成的表觀遺傳調(diào)控網(wǎng)絡(luò)，揭示它們協(xié)同介導(dǎo)核小體修飾、組裝和變構(gòu)等過程的分子機(jī)制。

2. 染色質(zhì)高級結(jié)構(gòu)的調(diào)控機(jī)制研究：以典型異染色質(zhì)高級結(jié)構(gòu)——端粒為范例開展異染色質(zhì)組裝和調(diào)控機(jī)制研究，揭示多個重要端粒結(jié)合蛋白和表觀遺傳因子維持和調(diào)控異染色質(zhì)高級結(jié)構(gòu)的具體分子機(jī)制，闡明細(xì)胞正常生理過程和病理過程中染色質(zhì)高級結(jié)構(gòu)變化及影響相應(yīng)功能變化的機(jī)制。

同時，我們還和其他課題組開展廣泛的合作研究，對生殖細(xì)胞發(fā)育調(diào)控和腫瘤分子生物學(xué)等方面具有濃厚興趣。

1. Wenqi Sun#, Qianhua Dong, Xueqing Li, Jinxin Gao, Xianwen Ye, Chunyi Hu, Fei Li*, Yong Chen* (2024) The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B, Nature Communications, 15, 4322
2. Jinxin Gao#, Wenqi Sun#, Jie Li, Hyoju Ban, Tuokai Zhang, Junwei Liao, Namho Kim, Soon Hoo Lee, Qianhua Dong, Robert Madramootoo, Yong Chen*, and Fei Li* (2023) Rex1BD and 14-3-3 protein control heterochromatin organization at tandem repeats by linking RNAi and HDAC, Proc. Natl. Acad. Sci. U S A.120(50) e2309359120
3. Yanjing Li*, Kexue Ge, Tingting Li, Run Cai, Yong Chen* (2023) The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications, Protein & Cell, 14，165-179 (review)
4. Yanjing Li#, Lijie Zhao#, Yuebin Zhang#, Ping Wu#, Ying Xu, Jun Mencius, Yongxin Zheng, Xiaoman Wang, Wancheng Xu, Naizhe Huang, Xianwen Ye, Ming Lei, Pan Shi, Changlin Tian, Chao Peng*, Guohui Li*, Zhijun Liu*, Shu Quan*, Yong Chen* (2022) Structural basis for product specificities of MLL family methyltransferases, Molecular Cell, 82, 3810-3825
5. Lijie Zhao, Naizhe Huang, Jun Mencius, Yanjing Li, Ying Xu, Yongxin Zheng, Wei He, Na Li, Jun Zheng, Min Zhuang, Shu Quan, Yong Chen (2022) DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates, iScience, 25(9): 104948
6. Duo Wang#, Fuxiang Yan#, Ping Wu#, Kexue Ge, Muchun Li, Tingting Li, Ying Gao, Chao Peng*, Yong Chen* (2022) Global profiling of regulatory elements in the histone benzoylation pathway, Nature Communication, 13：1369
7. Guochao Chen#, Duo Wang#, Bin Wu#, Fuxiang Yan, Hongjuan Xue, Shu Quan, Yong Chen* (2020) Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation, Nature Communication, 11:4206
8. Jianming Han, Tingting Li, Yanjing Li, Muchun Li, Xiaoman Wang, Chao Peng, Chen Su, Na Li, Yiwei Li, Ying Xu, Yong Chen* (2019) The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 47(19):10426-10438
9. Chunyi Hu^#, Haruna Inoue^#, Wenqi Sun^#, Yumiko Takeshita, Yaoguang Huang, Ying Xu, Junko Kanoh* and Yong Chen* (2019) Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 47(3): 1573-1584 (*co-corresponding author)
10. Qing Li^#, Yanjing Li^#, Suming Yang, Shuo Huang, Meng Yan,? Yifu Ding, Wei Tang, Xiwen Lou, Qi Yin, Zhanfei Sun, Lei Lu, Huijuan Shi, Hongyan Wang, Yong Chen* and Jinsong Li* (2018) CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell Biol. 20(11): 1315-1325 (*co-corresponding author)
11. Chunyi Hu ^#, Rekha Rai ^#, Chenhui Huang, Cayla Broton, Juanjuan Long, Ying Xu, Jing Xue, Ming Lei* , Sandy Chang* and Yong Chen*（2017）Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 27(12):1485-1502? (*co-corresponding author)
12. Yanjing Li, Jianming Han, Yuebin Zhang, Fang Cao, Zhijun Liu, Shuai Li, Jian Wu, Chunyi Hu, Yan Wang, Jin Shuai, Juan Chen, Liaoran Cao, Dangsheng Li, Pan Shi, Changlin Tian, Jian Zhang, Yali Dou, Guohui Li*, Yong Chen^*, and Ming Lei*(2016) Structural basis for activity regulation of MLL family methyltransferases，Nature, 530，447-452 (*co-corresponding author)