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　　1984年至1988就讀于南京大學生物系，獲學士學位。1992至1997年就讀于美國邁阿密大學醫學院生物化學與分子生物學系，獲博士學位。1998年至2001年在美國普林斯頓大學分子生物學系接受博士后訓練。2001年9月受聘于生物化學與細胞生物學研究所，任研究員，博士生導師，2002年2月至2007年1月，任中國科學院與德國馬普學會合作的青年科學家小組組長。

實驗室的長遠目標是探索真核細胞維持染色體穩定性的機制和細胞衰老的機理。真核細胞中的染色質分為常染色質和異染色質，處于常染色質區的基因表達活躍，而處于異染色質區的基因保持沉默。由于異染色質會擴展，常、異染色質之間會形成特異的“邊界”。該邊界的形成既有特異的DNA元件，也有染色質的修飾因子參與。在釀酒酵母中，位于染色體末端的端粒是研究染色質結構/功能、沉默、染色質邊界形成/調節、以及DNA復制/重組等表觀遺傳調控的很好的模型。端粒是由簡單的DNA重復序列及其結合蛋白組成。端粒對于維持染色體的穩定性，維持細胞連續分裂和防止細胞衰老具有非常重要的作用。在大多數真核生物中，端粒DNA是由特異性的反轉錄酶、即端粒酶合成的，在端粒酶缺失的情況下也可以由同源的重組途徑合成。另外，端粒也是一種典型的異染色質結構，能抑制相鄰的基因表達。
??????? 鑒于端粒的異染色質的特性，以及酵母基因組具有靈活的遺傳操作性，我們用酵母端粒作為特別的切入點來研究一些基礎問題，比如端粒是如何保持染色體穩定性的；在常染色質和異染色質之間的邊界是如何建立的；DNA雙鏈損傷或端粒復制發生時所產生的表觀遺傳信息是什么；細胞衰老的分子基礎又是什么。
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1. Yue Pan, Can Hu, Lin-Jun Hou, Yu-Long Chen, Jiantao Shi, Jia-Cheng Liu*, Jin-Qiu Zhou*. (2023) Swc4 protects nucleosome-free rDNA, tDNA and telomere loci to inhibit genome instability. DNA Repair 127, 103512.
2. Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou* and Yun Zhao*. (2023) Chromosome territory reorganization through artificial chromosome fusion is compatible with cell fate determination and mouse development. Cell Discovery 9:11.
3. Qian-Xi Li, Jia-Cheng Liu, Ming-Hong He and Jin-Qiu Zhou*. (2022) Kae1 of Saccharomyces cerevisiae KEOPS complex possesses ADP/GDP nucleotidase activity. Biochemical Journal 479(23): 2433–2447.
4. Xin Gu, Tiantian Ye, Xiao-Ran Zhang, Lingyun Nie, Huan Wang, Wei Li, Rui Lu, Chuanhai Fu, Li-Lin Du*and Jin-Qiu Zhou*. (2022) Single-chromosome fission yeast models reveal the configuration robustness of a functional genome. Cell Reports 40, 111237.
5. Jia-Cheng Liu, Qian-Jin Li, Ming-Hong He, Can Hu, Pengfei Dai, Fei-Long Meng, Bo O. Zhou and Jin-Qiu Zhou*. (2020) Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes. Nucleic Acids Research, 48(22): 12792–12803.
6. Zhi-Jing Wu, Jia-Cheng Liu, Xin Man, Xin Gu, Ting-Yi Li, Chen Cai, Ming-Hong He, Yangyang Shao, Ning Lu, Xiaoli Xue, Zhongjun Qin, Jin-Qiu Zhou*. (2020) Cdc13 is predominant over Stn1 and Ten1 in preventing chromosome end fusions. eLife 2020;9:e53144 DOI: 10.7554/eLife.53144.
7. Ting Gong#, Xin Gu#, Yu-Ting Liu, Zhen Zhou, Ling-Li Zhang, Yang Wen, Wei-Li Zhong, Guo-Liang Xu, Jin-Qiu Zhou*. (2020) Both combinatorial K4me0-K36me3 marks on sister histone H3s of a nucleosome are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation. Journal of Genetics and Genomics 47(2): 105-114.
8. Ming-Hong He#, Jia-Cheng Liu#, Yi-Si Lu, Zhi-Jing Wu, Ying-Ying Liu, Zhenfang Wu, Jing Peng, Jin-Qiu Zhou*. (2019) KEOPS complex promotes homologous recombination via DNA resection. Nucleic Acids Research 47(11): 5684-5697.
9. Yangyang Shao, Ning Lu, Chen Cai, Fan Zhou, Shanshan Wang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin*. (2019) A single circular chromosome yeast. Cell Research 29: 87-89.
10. Ling-Li Zhang, Zhenfang Wu, Jin-Qiu Zhou*. (2018) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. Journal of Genetics and Genomics 45(9): 467-476.
11. Zhenfang Wu*, Ming-Hong He, Ling-li Zhang, Jun Liu, Qiong-Di Zhang, Jin-Qiu Zhou*. (2018) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA Repair 72, 64-76.
12. Yangyang Shao, Ning Lu, Zhenfang Wu, Chen Cai, Shanshan Wang, Ling-Li Zhang, Fan Zhou, Shijun Xiao, Lin Liu, Xiaofen Zeng, Huajun Zheng, Chen Yang, Zhihu Zhao, Guoping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue* & Zhongjun Qin* (2018) Creating a functional single-chromosome yeast. Nature 560, 331-335.
13. Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou*. (2018) Yeast KEOPS complex regulates telomere length independently of its t6A modification function. Journal of Genetics and Genomics 45(5): 247-257
14. Zhen Zhou#, Yu-Ting Liu#, Li Ma, Ting Gong, Ya-nan Hu, Hong-Tao Li, Chen Cai Ling-Li Zhang, Gang Wei and Jin-Qiu Zhou*. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLIFE 6: e30178 DOI: 10.7554/eLife.30178
15. Xiaoguang Liu, Wei Wei, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li* and Jiemin Wong*. (2017) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300. Cell Discovery 3, 17016
16. 翻譯著作：《抗衰老革命》，周金秋等譯，“上?？茖W技術出版社”發行（ISBN 978-7-5478-3588-3）， 原著《The Telomerase Revolution》（原著作者：Michael Fossel，出版商：BenBella Books Inc.）。
17. Zhenfang Wu, Jun Liu, Qiong-Di Zhang, De-Kang Lv, Nian-Feng Wu and Jin-Qiu Zhou*. (2017) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Research 45(6): 3308-3322
18. Jun Liu*, Ming-Hong He, Jing Peng, Yi-Min Duan, Yi-Si Lu, Zhenfang Wu , Ting Gong, Hong-Tao Li, Jin-Qiu Zhou*. (2016) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast. Aging 8(11): 2827-2847
19. Yi-Min Duan, Bo-O Zhou, Jing Peng, Xia-Jing Tong, Qiong-Di Zhang and Jin-Qiu Zhou*. (2016) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast. Journal of Genetics and Genomics 43(7): 451-465
20. 細胞端粒藏著長壽的秘密（《人民日報》“科技大觀”版）（科普文章），劉軍，周金秋，《人民日報》， 2015年5月4日，22 版
21. Hong-Tao Li, Ting Gong, Zhen Zhou, Yu-Ting Liu, Xiongwen Cao, Yongning He, Charlie Degui Chen*, Jin-Qiu Zhou*. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochemical Journal 467(3): 507-515
22. Jing Peng, Ming-Hong He, Yi-Ming Duan, Yu-Ting Liu, Jin-Qiu Zhou*. (2015) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity. PLoS Genetics 11(3): e1005071
23. Fengjuan Lv, Tianlong Zhang, Zhen Zhou, Shuaixin Gao, Catherine CL Wong, Jin-Qiu Zhou, Jianping Ding*. (2015) Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell Discovery 1, 15037
24. Xiao-Hong Fu+, Yi-Min Duan+, Yu-Ting Liu, Chen Cai, Fei-Long Meng, Jin-Qiu Zhou*. (2014) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors. PLoS One 9(3): e90644
25. Yan Hu+, Hong-Bo Tang+, Ning-Ning Liu+, Xia-Jing Tong, Wei Dang, Yi-Min Duan, Xiao-Hong Fu, Yang Zhang, Jing Peng, Fei-Long Meng, Jin-Qiu Zhou*. (2013) Telomerase-null survivor screening identifies novel telomere recombination regulators. PLoS Genetics 9(1): e1003208
26. Qian-Jin Li, Xia-Jing Tong, Yi-Min Duan, Jin-Qiu Zhou*. (2013) Characterization of the intramolecular G-quadruplex promoting activity of Est1. FEBS Letter 587(6): 659-665
27. Jing Peng and Jin-Qiu Zhou*. (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Research 40(2): 581-593
28. Bo O. Zhou and Jin-Qiu Zhou*. (2011) Recent Transcription-induced Histone H3 Lysine 4 (H3K4) Methylation Inhibits Gene Reactivation. The Journal of Biological Chemistry 286(40): 34770-34776
29. Shan-Shan Wang, Bo O. Zhou*, and Jin-Qiu Zhou*. (2011) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 promoter. Molecular and Cellular Biology 31(15): 3171-3181
30. Xia-Jing Tong, Qian-Jin Li, Yi-Min Duan, Ning-Ning Liu, Ming-Liang Zhang, and Jin-Qiu Zhou*. (2011) Est1 protects telomeres and inhibits subtelomeric Y′-element recombination. Molecular and Cellular Biology 31(6): 1263-1274
31. Bo O. Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A. Lenzmeier, Jin-Qiu Zhou*. (2011) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae. PLoS Genetics 7(1): e1001272
32. Bo O. Zhou, Shan-Shan Wang, Lu-Xia Xu, Fei-Long Meng, Yao-Ji Xuan, Yi-Min Duan, Jian-Yong Wang, Hao Hu, Xianchi Dong, Jianping Ding, and Jin-Qiu Zhou*. (2010) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation. Molecular and Cellular Biology 30(10): 2391-2400
33. Liu NN, Han TX, Du LL and Zhou JQ (2010) A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. Cell Res. 20:963-965
34. Meng FL, Chen XF, Hu Y, Tang HB, Dang W and Zhou JQ (2010) Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Res. ?20:495-498
35. Ming-Liang Zhang, Xia-Jing Tong, Xiao-Hong Fu, Bo O. Zhou, Jianyong Wang, Xin-Hua Liao, Qian-Jin Li, Ning Shen, Jianping Ding, Jin-Qiu Zhou*. (2010) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation. Nature Structural & Molecular Biology. 17(2): 202-209.
36. Liu Y, Huang H, Zhou BO, Wang SS, Hu Y, Li X, Liu J, Zang J, Niu L, Wu J, Zhou JQ, Teng M, Shi Y. (2010) Structural analysis of Rtt106p reveals a DNA binding role required for heterochromatin silencing. J Biol Chem. 285:4251-62.
37. Jia-Lei Hu, Bo O. Zhou, Run-Rui Zhang, Kang-Ling Zhang, Jin-Qiu Zhou*, Guo-Liang Xu*. (2009) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc. Natl. Acad. Sci. 106: 187-192
38. Meng FL, Hu Y, Shen N, Tong XJ, Wang JY, Ding JP and Zhou JQ* (2009) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. ?EMBO J. 28: 1466-1478
39. Qian W, Wang JY, Jin NN, Fu XH, Lin YC, Lin JJ and Zhou JQ* (2009) Ten1p promotes the telomeric DNA binding acivity of Cdc13p: an implication for its function in telomere length regulation. Cell Res. 19: 850-863
40. Zhou J, Zhou BO, Lenzmeier BA and Zhou JQ (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res. 37: 3699-3713
41. Chen XF, Meng FL and Zhou JQ (2009) Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae. PLoS Genet. 5: e1000535
42. Fu XH, Meng FL, Hu Y and Zhou JQ (2008) Candida albicans, a distinctive fungal model for cellular aging study. Aging Cell 7:746-757
43. Yang CP, Chen YB, Meng FL and Zhou JQ (2006) Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo. Nucleic Acids Res. 34:407-416
44. Zhang DH, Zhou B, Huang Y, Xu LX and Zhou JQ (2006) The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. Nucleic Acids Res. 34:1393-1404
45. Chen YB, Yang CP, Li RX, Zeng R and Zhou JQ (2005) Def1p is involved in telomere maintenance in budding yeast. J. Biol. Chem. 280:24784-24791
46. Liao XH, Zhang ML, Yang CP, Xu LX and Zhou JQ (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem. J. 390:169-176
47. Zhou JQ*, Qi H*, Schulz VP, Mateyak MK, Monson EK and Zakian VA (2002) Schizosaccharomyces pombe pfh1(+) Encodes an Essential 5' to 3' DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases. Mol. Biol. Cell. 13:2180-2191 ?(*Co-first author)
48. Ivessa AS*, Zhou JQ*, Schulz VP, Monson EK and Zakian VA (2002) Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA. Genes & Dev. 16:1383-1396 ?(*Co-first author)
49. Zhou JQ, Monson EK, Teng SC, Schulz VP and Zakian VA (2000) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast. Science 289: 771-774
50. Ivessa AS*, Zhou JQ* and Zakian VA (2000) The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA. Cell 100: 479-489 ?(*Co-first author)
51. Zhou JQ, He H, Tan CK, Downey KM and So AG (1997) The small subunit is required for functional interaction of DNA polymerase delta with the proliferating cell nuclear antigen. Nucleic Acids Res. 27:1094-1099
52. Zhou JQ, Tan CK, So AG and Downey KM (1996) Purification and characterization of the human catalytic subunit of human DNA polymerase delta expressed in baculovirus-infected insect cells. J. Biol. Chem. 271:29740-29745

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