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　　2008年 蘭州大學(xué)，獲學(xué)士學(xué)位;

　　2013年 復(fù)旦大學(xué)，獲博士學(xué)位。

　　2014至2019年間， 威斯康星大學(xué)麥迪遜分校(University of Wisconsin Madison)

　　加州大學(xué)圣地亞哥分校 (University of California San Diego )

　　2019年8月底回國(guó)就任中國(guó)科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所研究員，研究組長(zhǎng)。

　　呼吸系統(tǒng)疾病是世界性的重大健康問(wèn)題。病毒，衰老及空氣污染引起的呼吸系統(tǒng)損傷會(huì)導(dǎo)致肺功能的持續(xù)性下降，并最終導(dǎo)致死亡。肺部特發(fā)性疾病如COPD和肺纖維化，目前在臨床上還缺乏有效的治療藥物。本實(shí)驗(yàn)室主要利用動(dòng)物模型和人類器官模型作為主要研究對(duì)象，結(jié)合多種前沿技術(shù)手段解碼肺再生的調(diào)控機(jī)制，為理解和治療肺部相關(guān)疾病提供新的思路和方法。

　　1、肺損傷修復(fù)的細(xì)胞基礎(chǔ)和通訊網(wǎng)絡(luò)

　　肺含有多種組織干細(xì)胞類型，在不同組織區(qū)域損傷情況下參與肺損傷修復(fù)的干細(xì)胞類型也不盡相同。我們想通過(guò)單細(xì)胞測(cè)序、譜系示蹤等技術(shù)手段鑒定參與肺再生的潛在干細(xì)胞類型，并解析調(diào)控特定肺干細(xì)胞功能的調(diào)控因子。

　　2、肺再生的細(xì)胞通訊網(wǎng)絡(luò)

　　肺是一個(gè)由中胚層和內(nèi)胚層來(lái)源的細(xì)胞構(gòu)成的復(fù)雜器官，在肺損傷再生過(guò)程中涉及多種細(xì)胞的協(xié)同作用。我們將通過(guò)組學(xué)分析結(jié)合條件敲除小鼠模型和類器官模型研究肺再生過(guò)程中細(xì)胞間的相互作用，揭示肺再生的細(xì)胞通訊網(wǎng)絡(luò)。

　　3、肺部疾病發(fā)生的分子機(jī)制

　　目前對(duì)于肺纖維化、COPD等呼吸系統(tǒng)疾病的發(fā)病機(jī)制目前還不明確，導(dǎo)致缺乏治療這些疾病的特效藥物。因此，我們將借助于肺疾病動(dòng)物模型和病人樣品，研究例如肺纖維化、COPD等疾病的發(fā)病機(jī)制并根據(jù)分子機(jī)制提出潛在的成藥靶點(diǎn)和新的治療策略。

1. Li Y, He Y, Zheng Q, Zhang J, Pan X, Zhang X, Yuan H, Wang G, Liu X, Zhou X, Zhu X, Ren T, Sui P. Mitochondrial pyruvate carriers control airway basal progenitor cell function through glycolytic-epigenetic reprogramming. Cell Stem Cell, https://doi.org/10.1016/j.stem.2024.09.015. (2024)
2. Lin X, Chen W, Yang G, Zhang J, Wang H, Liu Z, Xi Y, Ren T, Liu B, Sui P. Viral infection induces inflammatory signals that coordinate YAP regulation of dysplastic cells in lung alveoli. J Clin Invest. 134(19):e176828. doi: 10.1172/JCI176828. (2024)
3. Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, Zhao H, Xi Y, Sui P, Vaughan AE, Gillich A, Zhou B. Alveolar regeneration by airway secretory-cell-derived p63+?progenitors. Cell Stem Cell. S1934-5909(24)00291-1. doi: 10.1016/j.stem. (2024)
4. Wang S, Zhong S, Huang Y, Zhu S, Chen S, Wang R, Wangmo S, Peng B, Lv H, Yang J, Ma L, Ling Z, Zhang Y, Sui P, Sun B. MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53. J Innate Immun. 16(1):397-412. doi: 10.1159/000539824. (2024)
5. Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, Tong X, Patel AS, Misirlioglu S, Tang S, Huang HY, Geng K, Chen T, Karatza A, Sherman F, Labbe KE, Yang F, Chafitz A, Peng C, Guo C, Moreira AL, Velcheti V, Lau SCM, Sui P, Chen H, Diehl JA, Rustgi AK, Bass AJ, Poirier JT, Zhang X, Ji H, Zhang H, Wong KK. KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Cancer Cell. 41(1):88-105.e8. doi: 10.1016/j.ccell.(2023)
6. Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 11;57(7):839-853.e6. doi: 10.1016/j.devcel. (2022)
7. Li R, Zhang Y, Garg A, Sui P, Sun X. E3 ubiquitin ligase FBXW7 balances airway cell fates. Dev Biol. 483:89-97. doi: 10.1016/j.ydbio. (2021)
8. Xu Q, Wang C, Zhou JX, Xu ZM, Gao J, Sui P, Walsh CP, Ji H, Xu GL. Loss of TET reprograms Wnt signaling through impaired demethylation to promote lung cancer development. PNAS. 119(6):e2107599119. doi: 10.1073/pnas.2107599119. (2022)
9. Ma M, Yang W, Cai Z, Wang P, Li H, Mi R, Jiang Y, Xie Z, Sui P, Wu Y, Shen H. SMAD-specific E3 ubiquitin ligase 2 promotes angiogenesis by facilitating PTX3 degradation in MSCs from patients with ankylosing spondylitis. Stem Cells. 39(5):581-599. doi: 10.1002/stem.3332. (2021)
10. Sui P, Li R, Zhang Y, Tan C, Garg A, Verheyden JM, Sun X. E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size. Development. 146(24):dev179820. doi: 10.1242/dev.179820. (2019)
11. Garg A, Sui P, Verheyden JM, Young LR, Sun X. Consider the lung as a sensory organ: A tip from pulmonary neuroendocrine cells. Curr Top Dev Biol. 132:67-89. doi: 10.1016/bs.ctdb. (2019)
12. Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X. Pulmonary neuroendocrine cells amplify allergic asthma responses. Science. 360(6393):eaan8546. doi: 10.1126/science.aan8546. (2018)
13. Branchfield K, Nantie L, Verheyden JM, Sui P, Wienhold MD, Sun X. Pulmonary neuroendocrine cells function as airway sensors to control lung immune response. Science. 351(6274):707-10. doi: 10.1126/science.aad7969. (2016)
14. Herriges JC, Verheyden JM, Zhang Z, Sui P, Zhang Y, Anderson MJ, Swing DA, Zhang Y, Lewandoski M, Sun X. FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching. Dev Cell. 35(3):322-32. doi: 10.1016/j.devcel. (2015)
15. Sui P, Shi J, Gao X, Shen WH, Dong A. H3K36 methylation is involved in promoting rice flowering. Mol Plant. 6(3):975-7. doi: 10.1093/mp/sss152. (2013)
16. Sui P, Jin J, Ye S, Mu C, Gao J, Feng H, Shen WH, Yu Y, Dong A. H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice. Plant J. 70(2):340-7. doi: 10.1111/j.1365-313X. (2012)
17. Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen YT, Behringer RR, Sun X. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 137(20):3417-26. doi: 10.1242/dev.051789. (2010)