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　　1995年畢業(yè)于武漢大學，獲學士學位;2001年畢業(yè)于中科院上海生化所，獲博士學位。2001年11月至2012年1月于美國德州大學西南醫(yī)學中心從事博士后研究。2012年2月起，在中科院上海生物化學與細胞生物學研究所任研究員，研究組長。

　　當病原體入侵高等有機體時，會引發(fā)免疫反應，包括天然免疫和適應性免疫。天然免疫反應起始于宿主細胞的受體分子對病原體上的特異分子或者其它“異己”成分的識別，隨后激活特定的信號通路，誘導相應基因表達,防御病原體侵染。譬如當病毒感染細胞時，病毒相關的核酸分子會被細胞內的受體分子識別而激活相應的信號通路，誘導抗病毒的干擾素產生。天然免疫反應能夠為有機體提供及時的保護，但是其信號異常也可能導致自身免疫疾病等后果。腫瘤發(fā)生過程中產生的危險信號分子也可以激活天然免疫反應，誘導炎癥。我們近期聚焦RIG-I-MAVS信號通路，利用生物化學和分子生物學方法在細胞和動物水平上來解析其中的分子細胞機制，研究該信號通路與自身免疫疾病發(fā)生的相關性及其在腫瘤治療中的功能作用。

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