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人才隊伍

王紅艷
研究員，研究組長，博士生導師
E-mail: hongyanwang@@sibcb.ac.cn
實驗室主頁:

個人簡介：

　　1993-1998 年安徽醫科大學臨床醫學系本科;1998-2001 年安徽醫科大學免疫系和中國預防醫學科學院病毒所基因工程國家重點實驗室聯合培養碩士;2001-2006 英國倫敦帝國理工學院(Imperial College London)博士及Research Associate; 2006-2010 英國劍橋大學Research Fellow;2010年3月任生化與細胞所研究員，研究組長;2011年入選上海市浦江人才計劃。2014年獲國家基金委優秀青年資助。2018年獲國家自然基金委杰出青年資助。2015年獲中國科學院優秀指導老師稱號。

社會任職：

研究方向：

免疫細胞介導的炎癥相關疾病

研究工作：

　　免疫介導的炎癥相關疾病主要由于不適當或過度免疫反應造成的慢性和急性炎癥反應。其中，免疫系統中的T淋巴細胞和巨噬細胞能分泌各種炎癥/細胞因子，廣泛參與腫瘤或自身免疫性疾病的發生發展、機體抵御病原微生物感染的過程。(1)巨噬細胞通過Toll-樣受體等模式識別受體，感知病原微生物的各種組分，激活NF-kB、IRFs等各種轉錄因子，釋放促炎因子(IL-6，IL-1， TNF-alpha)或抑炎因子(IL-10)，或抗病毒的IFNs，調控炎癥反應，參與病原微生物感染和炎性癌變等過程。(2)在應對炎癥反應或異種抗原時，T淋巴細胞通過表面的眾多受體(如T細胞受體，趨化因子受體等)，調控T細胞定向遷移到感染或腫瘤等靶部位，增殖分化成具有殺傷功能的細胞毒性T淋巴細胞(CTL)，參與清除病原微生物或殺傷腫瘤細胞的過程。
　　我們利用基因工程突變小鼠及相應疾病模型，結合病人樣品，在分子、細胞水平，主要鑒定：(1)參與T細胞活化、增殖、遷移和殺傷功能的新型信號分子;(2)巨噬細胞調控炎癥反應和I型IFN的新型信號分子;(3) 上述信號分子、代謝酶或產物等調控巨噬細胞和T細胞參與抗感染、抗腫瘤或促進損傷修復中的功能和機制。
左圖Immunity, 2014, Cover Story；中圖：Cell Research, 2015, Cover Story；右圖：PLoS Pathogens, 2015

承擔科研項目情況：

代表論著：

1. J Xiao*, S Wang*, LL Chen*, XY Ding, MS Han, YX Zheng, MC Wang, D Yang, N Li, C Dong, H Shen, SF Wu, M Hu, C Su, WY Li, LJ Hui, YQ Ye#, HR Tang#, B Wei#, HY Wang#. 25-Hydroxycholesterol regulates lysosome AMPK activation and metabolic reprogramming to educate immunosuppressive macrophages, Immunity. 2024 Accept
2. X Zheng*, Q Jiang*, MS Han, FF Ye, MC Wang, Y Qiu, JL Wang, MX Gao, FJ Hou, and HY Wang#. FBXO38 regulates macrophage polarization to control the development of cancer and colitis, Cell Mol Immunol.?2023 Nov;20(11):1367-1378.
3. F Zhang*, BK Zhang*, HH Ding , XY Li, XL Wang , XM Zhang , QJ Liu , QY ?Feng , MS Han , LL Chen , LL Qi, D Yang , XJ ?Li , XG Zhu, Q Zhao, JQ Qiu, ZJ Zhu, HR Tang, N Shen#, HY Wang#, B Wei#. The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity to Limit IFN Response and Systemic Lupus Erythematosus, Adv Sci (Weinh). 2023 Sep;10(27):e2207108.
4. LL Qi*, XJ Li *, F Zhang * , XG ?Zhu , Q Zhao, D Yang , SJ Hao , T Li , XY ?Li , TK Tian , J Feng , XC Sun, XL Wang, SY Gao, HZ Wang , J Ye, SB Cao, YL He, HY Wang#, B Wei# . VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection, Cell Reports.?2023 May 30;42(5):112489.
5. D Yang, TK Tian, XJ Li, BK Zhang, LL Qi, F Zhang, MS Han, S Wang, J Xiao, YY Gou, RR Zhang, QJ Liu, S Su, JH Liu, XW Huang, Q Gao, LJ Hui, HR Tang, HY Wang#, B Wei#. ZNT1 and Zn2+ control TLR4 and PD-L1 endocytosis in macrophage to improve chemotherapy efficacy against liver tumor, Hepatology.?2023 Oct 9.?Online ahead of print.
6. X Zheng, J Xiao, Q Jiang, LM Zheng, C Liu, C Dong, YX Zheng, PL Ni, C Zhang, F Zhang, RY Zhong, HH Ding, Q Wang, Y Qiu, MX Gao, JP Ding, N Shen, B Wei#, HY Wang#. AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. EMBO J. 2022 Mar 15;41(6): e108016.
7. L Ma*, WY Li*, YB Zhang*, LL Qi*, Q Zhao, N Li, Y Lu, LQ Zhang, F Zhou, YC Wu, YN He, HX Yu, YL He#, B Wei#, HY Wang#. FLT4/VEGFR3 activates AMPK to coordinate glycometabolic reprogramming with autophagy and inflammasome activation for bacterial elimination. Autophagy. 2022 Jun;18(6):1385-1400.
8. XJ Li*, LL Qi*, D Yang, SJ Hao, F Zhang, XG Zhu, Y Sun, C Chen, J Ye, J Yang, L Zhao, D M Altmann, SB Cao, HY Wang#, B Wei#. Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system. Nat Neurosci. 2022 May;25(5):577-587.
9. C Zhang*, WY Li *, XB Lei, ZF Xie, LL Qi, H Wang, X Xiao, J Xiao, YX Zheng, C Dong, X Zheng, SY Chen, JF Chen, B Sun, J Qin, QW Zhai, JS Li, B Wei#, JW Wang#, HY Wang#. Targeting lysophospholipid acid receptor 1 and ROCK kinases promotes antiviral innate immunity. Sci Adv. 2021 Sep 17;7(38): eabb5933.
10. F Zhang*, LL Qi*, QY Feng, BK Zhang, XY Li, C Liu, WY Li, QJ Liu, D Yang, Y Yin, C Peng, H Wu, ZH Tang, X Zhou, Z Xiang, ZJ Zhang, HY Wang#, B Wei#. HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis. PNAS. 2021 Jul 13;118(28): e2021798118.
11. ZQ Li*, J Xiao*, XY Xu*, WY Li*, RY Zhong, LL Qi, JH Chen, GZ Cui, S Wang, YX Zheng, Y Qiu, S Li, X Zhou, Y Lu, JY Lyu, B Zhou, JW Zhou, NH Jing, B Wei#, J Hu#, HY Wang#. M-CSF, IL-6 and TGF-β promotes generation of a new subset of tissue repair macrophages for traumatic brain injury recovery. Sci Adv. 2021 Mar 12;7(11): eabb6260.
12. J Xiao*, WY Li *, X Zheng, LL Qi, H Wang, C Zhang, XP Wan, YX Zheng, RY Zhong, X Zhou, Y Lu, ZQ Li, Y Qiu, C Liu, F Zhang, YB Zhang, XY Xu, ZZ Yang, HL ?Chen, QW Zhai, B Wei#, Hongyan Wang #. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. Immunity. 2020 Jan 14;52(1):109-122.e6.
13. C Liu, XY Xu, L Han, XP Wan, LM Zheng, CY Li, J Xiao, RY Zhong, X Zheng, Q Wang, HL Chen, B Wei^#, H Wang^#. LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumor and pathogens. PNAS 2020;117(32):19388-19398
14. Q Wang^*, X Zhou^*, L Yang^*, YJ Zhao, ZH Chew, J Xiao, C Liu, X Zheng, YX Zheng, Q Shi,, QQ Liang^#, YJ Wang ^#*, H Wang^#. The natural compound Notopterol binds and targets JAK2/3 to ameliorate inflammation and arthritis. Cell Reports 2020;32:108158
15. Y Lu^*, Y Qiu^*, P Chen, H Chang, L Guo, F Zhang, L Ma, C Zhang, X Zheng, J Xiao, R Zhong, L Han, X Xu, Y Zhang, D Li, G Zhong, R Boyton, Y Huang, Y He, R Hu^#, B Wei^#, H Wang^# The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4-induced inflammation during bacterial infection. Nature Microbiology, 2019,4:2331-46
16. X Zhou, WY Li S Wang, P Zhang, Q Wang, J Xiao, C Zhang, X Zheng, X Xu, S Xue, L Hui, H Ji, B Wei#, H Wang#. YAP aggravates inflammatory bowel disease (IBD) via regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Reports, 2019, 27;1176-89
17. T Zhou#, MC Luo*, W Cai, SY Zhou, DY Feng, CD Xu, H. Wang#. Runt-related transcription factor 1 (RUNX1) promotes TGF-β-induced renal tubular epithelial-to-mesenchymal transition (EMT) and renal fibrosis through the PI3K subunit p110δ. EBioMedicine, 2018.31:217-225
18. Q Wang^*, X Zhou^*, YJ Zhao, J Xiao, Y Lu, Q Shi, YJ Wang#, H. Wang#, QQ Liang#. Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-kB Pathway. Frontiers in Immunology, 2018.9: article 2091.
19. XY Xu^*, L Han^*, G. Zhao, SJ Xue, Y Gao, J Xiao, ZY Wu, JP Ding, B Wei, RG Hu, H Wang. LRCH1 interferes with DOCK8-Cdc42 module-induced T cell migration and ameliorates multiple sclerosis. J Exp Med, 2017; 214(1):209-226.
20. SJ Xue^*, C Liu^*, XJ Sun, WY Li, C Zhang, X Zhou, Y Lu, J Xiao, CY Li, XY Xu, B Sun, GL Xu, H Wang. TET3 inhibits IFN-I production independent of DNA demethylation. Cell Reports, 2016;16:1-10
21. Luo MC^*, Zhou SY^*, Feng DY, Xiao J, Li WY, Xu CD, Wang HY#, Zhou T#. Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock. J Biol Chem. 2016;291 (42), 22011-22020.
22. WY Li^*, J Xiao^*, X Zhou, M Xu, C Hu, X Xu, Y Lu, CLiu, S Xue, LNie, H Zhang, ZLi, Y Zhang, F Ji, L Hui, W Tao, B Wei# and H Wang#, STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma. J Clin Invest, 2015; 125(11):4239-54
23. Li C^*, Jiao S^*, Wang G, Gao Y, He X, Liu C, Zhang G, Wei B, Chen H#, Wang H#. The immune adaptor ADAP regulates reciprocal TGF-b1-integrin crosstalk to protect from H5N1 influenza virus infection. PLoS Pathogens, 2015, 11(4):e1004824
24. Fu X^*, Xiao J^*, Wei Y, Guo H, Li S, Liu Y, Yin J, Li D, Wang H#, Hu P#. Combination of four pro-inflammatory cytokines promotes long term muscle stem cell expansion in vitro. Cell Research, 2015, 25:655-73 (Cover Story)
25. Zhang Y^*, Lu Y^*, Ma L, Jiao S, Chen J, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B#, Wang H# Activation of vascular endothelial growth factor receptor-3 in macrophages restrains TLR-NF-kB signaling and protects from endotoxin shock. Immunity, 2014, 40: 501-514 (Cover Story)
26. Huang Y^*, Jiao S^*, Tao X, Tang Q#, Jiao W, Xiao J, Xu X, Zhang Y, Liang G, Wang H # Met-CCL5 represents an immunotherapy strategy to ameliorate rabies virus infection. J Neuroinflammation 2014,11:146;
27. Wei B*, Han L*, Abbink T, Elisabetta G, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H# and Rudd CE#. Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology, 2013:10:101
28. Zhang Y and Wang H#. Integrin signaling and function in immune cells. Immunology, 2012;4(135):267-75
29. Wang H#, Lim D and Rudd CE. Integrin signaling and immunopathology Semin Immunopathol 2010;32(2):173-82
30. Wang H, Wei B, Bismuth G, Rudd CE. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility. PNAS 2009; 106(30):12436-41.
31. Wang H and Rudd CE. SKAP-55, SKAP-55Related and ADAP adaptors modulate integrin-mediated immune cell adhesion. Trends Cell Biol 2008; 18(10):486-93.
32. Wang H, Liu H, Lu Y, Lovatt M, Wei B, Rudd CE. Functional defects of SKAP-55 deficient T-cells identify a regulatory role for the adaptor in LFA-1 adhesion. Mol Cell Biol. 2007;27(19):6863-75
33. Wang H, McCane F, Gordan J, Wu X, Raab M, Malik T, Davis D, Rudd CE. ADAP-SLP-76 binding differently regulates the supramolecular activation complex (SMAC) formation vs. conjugate formation. J. Exp. Med. 2004;200:1063-1074
34. Wang H*, Moon EY*, Azouz A, Wu X, Smith A, Schneider H, Hogg N, Rudd CE. SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates. Nat Immunol. 2003;4(4):366-74.

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