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　　1935年2月20日生于上海市，九三學(xué)社社員。1957年9月畢業(yè)于上海復(fù)旦大學(xué)化學(xué)系。1957年至今在中國(guó)科學(xué)院上海生化細(xì)胞所進(jìn)行科研(研究實(shí)習(xí)員，助理研究員，副研究員，研究員，科學(xué)院院士)。從事放射生物學(xué)、激素對(duì)基因轉(zhuǎn)錄調(diào)控，近十年來進(jìn)行精子在附睪中成熟的分子機(jī)制研究。1983-1999年間在英國(guó)ICRF、美國(guó)Chicago大學(xué)、Wisconsin大學(xué)(Madison)、North Carolina大學(xué)、荷蘭ERUSMUS大學(xué)、澳大利亞Sydney大學(xué)等進(jìn)行合作科研。從1993年至今，先后獲得國(guó)家自然科學(xué)三等獎(jiǎng)和二等獎(jiǎng)、中科院自然科學(xué)一等獎(jiǎng)、第二屆科技十大女杰、上海市自然科學(xué)一等獎(jiǎng)和科技功臣和何梁何利生命科學(xué)獎(jiǎng)等。

主要從事雄激素對(duì)真核基因轉(zhuǎn)錄調(diào)控機(jī)制研究和睪丸生精過程中及附睪對(duì)精子成熟過程中的基因表達(dá)程序的調(diào)控，現(xiàn)集中在附睪功能基因組研究。該實(shí)驗(yàn)室由張友端教授在1978年建立，她于1989年退居二線做顧問后，由其學(xué)生張永蓮教授擔(dān)任課題組長(zhǎng)。由于這是我國(guó)第一個(gè)從事這一飛速發(fā)展的領(lǐng)域的研究室。因此他們首先建立了各種激素受體的測(cè)定方法，并以培訓(xùn)班的形式向全國(guó)推廣，以填補(bǔ)我國(guó)這一領(lǐng)域在研究和臨床應(yīng)用方面的空白。然后進(jìn)行了雌激素受體的純化，制備單克隆抗體等基礎(chǔ)工作。同時(shí)篩選了研究激素作用原理的靶基因系統(tǒng)，通過對(duì)大鼠前列腺中PSBP基因表達(dá)的時(shí)空秩序以及雄激素影響下的特征，證明了它是研究雄激素對(duì)真核基因轉(zhuǎn)錄的調(diào)控機(jī)制的一個(gè)理想系統(tǒng)。通過對(duì)PSBP的C3基因啟動(dòng)子上的順式調(diào)控元件和細(xì)胞核中的反式作用因子相互作用的研究，發(fā)現(xiàn)了啟動(dòng)子上的一些重要元件如：TATA盒和CCAAT盒上除了有一些通用因子與之作用外，還有組織特異的和雄激素調(diào)控相關(guān)的因子與之直接或間接地結(jié)合然后起協(xié)同作用。這些成果獲得了1993年的中國(guó)科學(xué)院的自然科學(xué)一等獎(jiǎng)，1997年國(guó)家自然科學(xué)三等獎(jiǎng)。為了深入了解多元件，多因子的相互作用中的調(diào)控激發(fā)程序，該課題組進(jìn)而開始研究基因轉(zhuǎn)錄活性與染色體結(jié)構(gòu)的關(guān)系。

此外，為了將基礎(chǔ)研究與生物學(xué)重大問題相結(jié)合，我們已開始研究睪丸生精過程及附睪對(duì)精子成熟過程中的基因表達(dá)程序的調(diào)控，以期能為男性健康生育調(diào)控的藥物設(shè)計(jì)提供新的思路。附睪是一根連接睪丸和輸精管的盤曲的細(xì)長(zhǎng)管道。但不同部位的附睪細(xì)胞表達(dá)不同的基因，管腔中分泌的種類各異的蛋白質(zhì)與從睪丸中分化完全的精子相互作用，使精子表面蛋白質(zhì)的成分得以部分改變或修飾，從而使精子逐步獲得運(yùn)動(dòng)、獲能、精卵結(jié)合等能力而成熟，被儲(chǔ)存在其尾部等待射精。本組目標(biāo)是克隆附睪特異表達(dá)的基因，建立一個(gè)研究精子成熟功能的測(cè)試平臺(tái)去研究這些基因在精子成熟中的作用及其表達(dá)調(diào)控。這不僅有助于揭示精子在附睪中成熟的分子機(jī)理，而且為解決精子成熟異常所引起的不孕癥的診斷和治療和開發(fā)一些阻斷精子成熟的男性避孕藥物研制提供新的藥靶和設(shè)計(jì)思路。
        目前有三方面的工作進(jìn)行重點(diǎn)開展：
        (1) 附睪特異表達(dá)的新蛋白在精子成熟中的功能(條件性knock out/in)；
        (2) 附睪特異表達(dá)的miRNA在精子成熟中的作用；
        (3) 表觀遺傳修飾(DNA methylation & histon modification)在附睪和精子成熟中的作用。

目前正聯(lián)合所內(nèi)外力量，優(yōu)勢(shì)互補(bǔ)，在此基礎(chǔ)上趁勝追擊，為我國(guó)附睪與精子相關(guān)的功能基因組學(xué)和男性節(jié)育和不育作出更大的供獻(xiàn)。實(shí)驗(yàn)室已經(jīng)和國(guó)際上的許多實(shí)驗(yàn)室有合作課題，遍及美國(guó)、英國(guó)、澳大利亞和香港地區(qū)。目前，課題經(jīng)費(fèi)來源國(guó)于國(guó)家自然科學(xué)基金委、中國(guó)科學(xué)院、上海市科委及美國(guó)NIH國(guó)際合作項(xiàng)目等。

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