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人才隊伍

趙祥
研究員，研究組長，博士生導師
E-mail: xiang.zhao@sibcb.ac.cn
實驗室主頁:

個人簡介：

2009-2013年，復旦大學生命科學學院，生物科學學士
2013-2018年，新加坡國立大學醫學院，免疫學博士
2018-2023年，斯坦福大學醫學院，博士后
2023年6月起任中國科學院分子細胞科學卓越創新中心（生物化學與細胞生物學研究所）研究員，研究組長，博士生導師

社會任職：

研究方向：

T細胞免疫與T細胞受體

研究工作：

T細胞受體（TCR）結合配體peptide-MHC，是免疫系統識別多種多樣抗原的分子基礎。課題組綜合運用生物化學、細胞生物學、免疫學、蛋白質工程、結構生物學、遺傳學、生物物理學等方法，以T細胞與T細胞受體為主要研究對象，深入研究T細胞受體的抗原識別與信號轉導機制，發展針對實體腫瘤的TCR-T細胞療法。
具體方向包括：
　　1.T細胞受體抗原識別與信號轉導的新機制;
　　2.T細胞受體等免疫受體的蛋白質工程改造新技術;
　　3.T細胞抗原識別與信號轉導的結構基礎;
　　4.多學科賦能的實體腫瘤特異TCR-T細胞療法;
　　5.鑒定新型的免疫受體-配體。
主持項目：
　　國家自然科學基金委員會原創探索計劃(主持，2024-2026)
　　中國科學院率先行動(主持，2024-2026)
　　上海市白玉蘭人才計劃浦江項目(主持，2023-2025)

承擔科研項目情況：

代表論著：

1. Zhao*, X., Shao, S., and Hu, L. (2024). The recent advancement of TCR-T cell therapies for cancer treatment. Acta Biochim. Biophys. Sin. https://doi.org/10.3724/abbs.2024034.
2. Ren, F., Wang, F., Baghdasaryan, A., Li, Y., Liu, H., Hsu, R., Wang, C., Li, J., Zhong, Y., Salazar, F., et al. (2024). Shortwave-infrared-light-emitting probes for the in vivo tracking of cancer vaccines and the elicited immune responses. Nat. Biomed. Eng. 8, 726–739. https://doi.org/10.1038/s41551-023-01083-5.
3. Yang, X., Nishimiya, D., L?chte, S., Jude, K.M., Borowska, M., Savvides, C.S., Dougan, M., Su, L., Zhao, X., Piehler, J., et al. (2023). Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy. Nat Biotechnol, 1–12. https://doi.org/10.1038/s41587-022-01567-w.
4. Chan, W., Cao, Y.M., Zhao, X., Schrom, E.C., Jia, D., Song, J., Sibener, L.V., Dong, S., Fernandes, R.A., Bradfield, C.J., et al. (2023). TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. J. Exp. Med. 220, e20231242. https://doi.org/10.1084/jem.20231242.
5. Zhao, X., Kolawole, E.M., Chan, W., Feng, Y., Yang, X., Gee, M.H., Jude, K.M., Sibener, L.V., Fordyce, P.M., Germain, R.N., et al. (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.) 376, eabl5282. https://doi.org/10.1126/science.abl5282.Nat Rev Drug Discov綜述點評Nat Rev Clin Oncol綜述點評F1000推薦美國授權PCT專利PCT/US2022/018975
6. Yang, X., Garner, L.I., Zvyagin, I.V., Paley, M.A., Komech, E.A., Jude, K.M., Zhao, X., Fernandes, R.A., Hassman, L.M., Paley, G.L., et al. (2022). Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 1–7. https://doi.org/10.1038/s41586-022-05501-7.
7. Yen, M., Ren, J., Liu, Q., Glassman, C.R., Sheahan, T.P., Picton, L.K., Moreira, F.R., Rustagi, A., Jude, K.M., Zhao, X., et al. (2022). Facile discovery of surrogate cytokine agonists. Cell. https://doi.org/10.1016/j.cell.2022.02.025.
8. Feng, Y., Zhao, X., White, A.K., Garcia, K.C., and Fordyce, P.M. (2022). A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation. Nat Methods, 1–11. https://doi.org/10.1038/s41592-022-01592-2.
9. Wu, L., Balyan, R., Brzostek, J., Zhao, X., and Gascoigne, N.R.J. (2022). Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response. Embo Rep, e54969. https://doi.org/10.15252/embr.202254969.
10. Zhao, X., Wu, L.-Z., Ng, E.K.Y., Leow, K.W.S., Wei, Q., Gascoigne, N.R.J., and Brzostek, J. (2021). Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck. Frontiers in immunology 12, 721722. https://doi.org/10.3389/fimmu.2021.721722.
11. Brzostek, J., Gautam, N., Zhao, X., Chen, E.W., Mehta, M., Tung, D.W.H., Chua, Y.L., Yap, J., Cho, S.H., Sankaran, S., et al. (2020). T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis. Nature immunology 21, 186–198. https://doi.org/10.1038/s41590-019-0570-3.
12. Wei, Q., Brzostek, J., Sankaran, S., Casas, J., Hew, L.S.-Q., Yap, J., Zhao, X., Wojciech, L., and Gascoigne, N.R.J. (2020). Lck bound to coreceptor is less active than free Lck. Proceedings of the National Academy of Sciences of the United States of America 117, 15809–15817. https://doi.org/10.1073/pnas.1913334117.
13. Zhao, X., Hamidinia, M., Choo, J.A.L., Too, C.T., Ho, Z.Z., Ren, E.C., Bertoletti, A., MacAry, P.A., Gould, K.G., Brzostek, J., et al. (2019). Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation. J. Vis. Exp. https://doi.org/10.3791/59126-v.
14. Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019). In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Nature biotechnology 37, 1322–1331. https://doi.org/10.1038/s41587-019-0262-4.
15. Zhao, X., Sankaran, S., Yap, J., Too, C.T., Ho, Z.Z., Dolton, G., Legut, M., Ren, E.C., Sewell, A.K., Bertoletti, A., et al. (2018). Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling. Nature communications 9, 2716. https://doi.org/10.1038/s41467-018-05288-0.

個人簡介：

社會任職：

研究方向：

研究工作：

承擔科研項目情況：

代表論著：

獲獎及榮譽：

研究組成員：